Spatial proteomics

While proteomics approaches have facilitated the analysis of proteins present in cells and tissues, spatial proteomics have enabled the delineation of proteins’ spatial localization within cells, which has enhanced our understanding of their form and function. Different methods have emerged in the past years to visualize protein positioning, which might vary as a function of cell type, cell cycle progression or disease state. Spatial proteomics has thereby provided unprecedented insight into biological processes not only from a fundamental cell biology perspective, but also from a clinical perspective, to study how protein localization changes in pathogenic cells, which could prove useful for finding biomarkers and developing new therapies. This collection highlights some of the advances of the past year in this rapidly evolving field.

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