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Infection with the SARS CoV-2 virus can lead to symptoms that persist for weeks, months, or even years after the acute phase of infection has passed. These symptoms may include fatigue, shortness of breath, difficulty concentrating, loss of taste and smell, heart palpitations, headache, and muscle pain, among others. While estimates vary on the prevalence of long COVID – also known as post-COVID, long-haul COVID, chronic COVID, post-acute COVID-19, and post-acute sequelae COVID-19, or PASC – it is increasingly clear that a substantial proportion of COVID-19 survivors will experience at least one lingering COVID-related symptom. The mechanisms underlying this phenomenon are poorly understood; leading hypotheses include a prolonged inflammatory response, the triggering of autoimmunity, and the presence of viral reservoirs in the body.

This Collection invites research on the causes, risk factors, and frequency of long COVID, as well as on the development of diagnostic tools and treatments.

A man hauling a 3D virus infection with ropes, representing Long Covid syndrome and coronavirus pandemic symptoms that persist as a burden concept or being tied/trapped.


  • Nicolas G. Bazan

    LSU Health New Orleans, USA

  • Artur Fedorowski

    Karolinska University Hospital, Sweden; Karolinska Institute, Sweden

  • Seyed Ehtesham Hasnain

    Indian Institute of Technology, India; Sharda University, India

  • Roxana Moslehi

    University at Albany - State University of New York, USA

  • Annette Regan

    University of San Francisco, USA