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The tumour microenvironment is defined as the collection of cells, molecules and vasculature directly around a tumour that adapts specifically in response to the disease. It is influenced both by the tumour to promote growth and by the host to help control disease. Researchers are unravelling the dynamics of these environments to understand how to model, define and fight tumours using multidisciplinary approaches. Here we present a selection of articles from a variety of fields outlining some of the work being done within this growing research topic.