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Researchers the world over are fast adopting CRISPR-Cas9 to tinker with the genomes of humans, viruses, bacteria, animals and plants. Nature brings together research, reporting and expert opinion to keep you abreast of the frontiers of gene editing.

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Research & Review

  • Nature | News & Views

    The gene-editing technology CRISPR–Cas has been used in human embryos grown in vitro to correct a disease-associated mutation. The introduction of editing components at fertilization aided repair efficiency. See Article p.413

    • Nerges Winblad
    •  &  Fredrik Lanner
  • Nature | News & Views

    Bacteria and archaea use an innate immune system called CRISPR–Cas to combat viral infection. The identification of a family of molecules that play a key part in this system deepens our understanding of such immunity. See Article p.543

    • Kaitlin Johnson
    •  &  Scott Bailey
  • Nature | News & Views

    A system that introduces random modifications to barcode sequences embedded in cells' DNA allows lineage relationships between cells to be discerned, while preserving the cells' spatial relationships. See Letter p.107

    • Lauren E. Beck
    •  &  Arjun Raj
  • Nature | News & Views

    The enzyme Cas9 is used in genome editing to cut selected DNA sequences, but it also creates breaks at off-target sites. Protein engineering has now been used to make Cas9 enzymes that have minimal off-target effects. See Article p.490

    • Fyodor Urnov
  • Nature | News & Views

    Study of the diarrhoea-causing pathogen Cryptosporidium has been hindered by a lack of genetic-modification and culture tools. A description of genome editing and propagation methods for the parasite changes this picture. See Letter p.477

    • Stephen M. Beverley
  • Nature | News & Views

    Bacteria use CRISPR–Cas systems to develop immunity to viruses. Details of how these systems select viral DNA fragments and integrate them into bacterial DNA to create a memory of invaders have now been reported. See Articles p.193 & p.199

    • Ido Yosef
    •  &  Udi Qimron