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Electromagnetic devices involving a vibratory actuator and a soft strain-sensing sheet can dynamically measure the Young’s modulus of skin and of other soft biological tissues at depths of millimetres.
Large-scale single-neuron recordings from hearing-impaired gerbils show that compression and amplification algorithms used in hearing aids restore the sensitivity of neural responses to speech, but not their selectivity.
A skin-worn device that simultaneously monitors blood pressure and heart rate via ultrasonic transducers and multiple biomarkers via electrochemical sensors captures physiological effects of food intake and exercise in human volunteers.
Customized soft electrode arrays that are well adjusted to specific anatomical environments, functions and experimental models can be rapidly prototyped via the robotically controlled deposition of conductive inks and insulating inks.
An integrated system consisting of conformable piezoelectric devices, three-dimensional digital image correlation, multiphysics modelling and real-time classification algorithms predicts facial kinematics and decodes facial deformations.
A wireless device designed to be conformally placed on the suprasternal notch can continuously provide real-time information of essential vital signs as well as talking time, swallow counts and sleep patterns.
Functionalized multi-walled carbon nanotubes twisted into helical fibre bundles that mimic the hierarchical structure of muscle can be used for the long-term monitoring of multiple disease biomarkers in vivo.
Body-scale epidermal electronic interfaces for electrophysiological recordings enable the control of a transhumeral prosthesis, long-term electroencephalography, and simultaneous electroencephalography and structural and functional MRI.
Conductive and elastic hydrogel-based microelectronic arrays with high current-injection density and low interfacial impedance with tissue enable the localized low-voltage electrical stimulation of the sciatic nerve in live mice.
A closed-loop and wireless 128-channel neuromodulation device enables electrical stimulation as well as artefact-free long-term recording of local field potentials in the brain of an untethered non-human primate.
Implantable inductively coupled resonant circuits that change their properties in response to electrical or photonic cues and are detectable in magnetic resonance imaging enable the remote sensing of bioluminescence in rodent brains.
Bioresorbable pressure sensors with significantly improved operational lifetimes, as exemplified via the monitoring of intracranial pressure in rats for over 25 days, can be similarly accurate to analogous non-resorbable clinical devices.
An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.
An implantable, wirelessly powered optoelectronic device that adheres to tissue for the delivery of low-dose, long-term photodynamic therapy leads to significant antitumour effects in mice with intradermally transplanted tumours.
A phased electromagnetic surface that conforms to the body surface can regulate cardiac rhythm in a porcine model through the wireless transmission of power to miniaturized semiconductor devices implanted at depths of over 4 cm.
Capacitive coupling between tissue and flexible integrated electronics through a sealing dielectric layer facilitates long-term electrophysiology measurements, as demonstrated in ex vivo Langendorff heart models.