p53: Recent Facts and New Questions

This Special Issue of Cell Death & Differentiation brings together a set of articles focused on p53. Almost four decades of research and thousands of publications have firmly established p53 as one of the most frequently altered genes in cancer and the hub of the cell response to stress. Yet, new functions continue to emerge adding further complexity but also providing new translational avenues. Read through to explore recent findings on p53 mutants, family members, mechanisms of tumor suppression, regulation of ferroptosis and response to DNA replication and ribosome biogenesis stress, while challenged by the thought-provoking questions posed by leading scientists in the field.

Infographic of the roles of p53


Reviews and Perspectives


Comment and Correspondence