Scientific Reports

Collection 12 March 2023

Top 100 in Cancer - 2022

This collection highlights our most downloaded* cancer papers published in 2022. Featuring authors from aroud the world, these papers showcase valuable research from an international community.

You can also view the top papers across various subject areas here.

*Data obtained from SN Insights, which is based on Digital Science's Dimensions.

1-25

Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)
- Nerea Allende-Vega
- Joaquin Marco Brualla
- Martin Villalba
ArticleOpen Access25 Jan 2022 Scientific Reports
T cell subtype profiling measures exhaustion and predicts anti-PD-1 response
- Ian Schillebeeckx
- Jon Earls
- Jarret I. Glasscock
ArticleOpen Access25 Jan 2022 Scientific Reports
A cross-sectional study of clinical, dermoscopic, histopathological, and molecular patterns of scalp melanoma in patients with or without androgenetic alopecia
- Ana Carolina Porto
- Tatiana Pinto Blumetti
- J. Casagrande Tavoloni Braga
ArticleOpen Access5 Sep 2022 Scientific Reports
Deep learning-based algorithm for lung cancer detection on chest radiographs using the segmentation method
- Akitoshi Shimazaki
- Daiju Ueda
- Yukio Miki
ArticleOpen Access14 Jan 2022 Scientific Reports
Lapatinib as first-line treatment for muscle-invasive urothelial carcinoma in dogs
- Shingo Maeda
- Kosei Sakai
- Yasuyuki Momoi
ArticleOpen Access13 Jan 2022 Scientific Reports
Different syngeneic tumors show distinctive intrinsic tumor-immunity and mechanisms of actions (MOA) of anti-PD-1 treatment
- Ying Jin
- Xiaoyu An
- Xuesong Ouyang
ArticleOpen Access28 Feb 2022 Scientific Reports
Survival Genie, a web platform for survival analysis across pediatric and adult cancers
- Bhakti Dwivedi
- Hope Mumme
- Manoj Bhasin
ArticleOpen Access23 Feb 2022 Scientific Reports
MACSima imaging cyclic staining (MICS) technology reveals combinatorial target pairs for CAR T cell treatment of solid tumors
- Ali Kinkhabwala
- Christoph Herbel
- Andreas Bosio
ArticleOpen Access3 Feb 2022 Scientific Reports
Efficient prediction of a spatial transcriptomics profile better characterizes breast cancer tissue sections without costly experimentation
- Taku Monjo
- Masaru Koido
- Yoichiro Kamatani
ArticleOpen Access8 Mar 2022 Scientific Reports
Detection of rare prostate cancer cells in human urine offers prospect of non-invasive diagnosis
- Nima Sayyadi
- Irene Justiniano
- James A. Piper
ArticleOpen Access2 Nov 2022 Scientific Reports
Efficacy of adjuvant trastuzumab in women with HER2-positive T1a or bN0M0 breast cancer: a population-based cohort study
- Sanji Ali
- Jace Hendry
- Shahid Ahmed
ArticleOpen Access20 Jan 2022 Scientific Reports
Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer
- Yara Abdou
- Medhavi Gupta
- Kazuaki Takabe
ArticleOpen Access4 Aug 2022 Scientific Reports
A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer
- Cowan Ho
- Zitong Zhao
- Wei-Qiang Leow
ArticleOpen Access9 Feb 2022 Scientific Reports
A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors
- Julie K. Fierle
- Johan Abram-Saliba
- Steven M. Dunn
ArticleOpen Access21 Jan 2022 Scientific Reports
Extrachromosomal DNA formation enables tumor immune escape potentially through regulating antigen presentation gene expression
- Tao Wu
- Chenxu Wu
- Xue-Song Liu
ArticleOpen Access4 Mar 2022 Scientific Reports
Survival, treatment regimens and medical costs of women newly diagnosed with metastatic triple-negative breast cancer
- Ju-Yi Hsu
- Chee-Jen Chang
- Jur-Shan Cheng
ArticleOpen Access14 Jan 2022 Scientific Reports
A prognostic model of non small cell lung cancer based on TCGA and ImmPort databases
- Dongliang Yang
- Xiaobin Ma
- Peng Song
ArticleOpen Access10 Jan 2022 Scientific Reports
Updated fraction of cancer attributable to lifestyle and environmental factors in Denmark in 2018
- Anne Julie Tybjerg
- Søren Friis
- Brian Køster
ArticleOpen Access11 Jan 2022 Scientific Reports
In vitro characterization of a small molecule PD-1 inhibitor that targets the PD-l/PD-L1 interaction
- Chih-Hao Lu
- Wei-Min Chung
- Huey-En Tzeng
ArticleOpen Access7 Jan 2022 Scientific Reports
The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer
- Miya Haruna
- Azumi Ueyama
- Hisashi Wada
ArticleOpen Access30 Mar 2022 Scientific Reports
Real-time high-resolution millimeter-wave imaging for in-vivo skin cancer diagnosis
- Amir Mirbeik
- Robin Ashinoff
- Negar Tavassolian
ArticleOpen Access23 Mar 2022 Scientific Reports
Refined characterization of circulating tumor DNA through biological feature integration
- Havell Markus
- Dineika Chandrananda
- Nitzan Rosenfeld
ArticleOpen Access4 Feb 2022 Scientific Reports
Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model
- Julie A. Zorn
- Matthew L. Wheeler
- Pavel Strop
ArticleOpen Access3 Mar 2022 Scientific Reports
Transgenic expression of IL-7 regulates CAR-T cell metabolism and enhances in vivo persistence against tumor cells
- Li Li
- Qing Li
- Wei-Li Zhao
ArticleOpen Access22 Jul 2022 Scientific Reports
Differences between human and machine perception in medical diagnosis
- Taro Makino
- Stanisław Jastrzębski
- Krzysztof J. Geras
ArticleOpen Access27 Apr 2022 Scientific Reports

26-50

A deep learning system for prostate cancer diagnosis and grading in whole slide images of core needle biopsies
- Nitin Singhal
- Shailesh Soni
- Arvind Ganpule
ArticleOpen Access1 Mar 2022 Scientific Reports
Half of germline pathogenic and likely pathogenic variants found on panel tests do not fulfil NHS testing criteria
- Tala Andoni
- Jennifer Wiggins
- Rosalind Eeles
ArticleOpen Access21 Feb 2022 Scientific Reports
Survival benefit with adjuvant chemotherapy in stage III microsatellite-high/deficient mismatch repair colon cancer: a systematic review and meta-analysis
- Gianluca Tomasello
- Michele Ghidini
- Fausto Petrelli
ArticleOpen Access20 Jan 2022 Scientific Reports
Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy
- Ethan Shelkey
- David Oommen
- Shay Soker
ArticleOpen Access15 Jun 2022 Scientific Reports
Single cell RNA sequencing reveals differentiation related genes with drawing implications in predicting prognosis and immunotherapy response in gliomas
- Zijian Zhou
- JinHong Wei
- Luo Li
ArticleOpen Access3 Feb 2022 Scientific Reports
Dual-sgRNA CRISPR/Cas9 knockout of PD-L1 in human U87 glioblastoma tumor cells inhibits proliferation, invasion, and tumor-associated macrophage polarization
- Javier Fierro Jr.
- Jake DiPasquale
- Huanyu Dou
ArticleOpen Access14 Feb 2022 Scientific Reports
Extracellular vesicles released by non-small cell lung cancer cells drive invasion and permeability in non-tumorigenic lung epithelial cells
- Humna Hasan
- Ikjot Singh Sohal
- Andrea L. Kasinski
ArticleOpen Access19 Jan 2022 Scientific Reports
Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma
- Michael Naidoo
- Leanne Jones
- Lee R. Machado
ArticleOpen Access25 Feb 2022 Scientific Reports
Assessment of factors associated with PSA level in prostate cancer cases and controls from three geographical regions
- Nishi Karunasinghe
- Tsion Zewdu Minas
- Lynnette R. Ferguson
ArticleOpen Access7 Jan 2022 Scientific Reports
The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer
- Shota Ishihara
- Kenji Hata
- Toshiyuki Yoneda
ArticleOpen Access15 Apr 2022 Scientific Reports
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition
- Tereza Vaclova
- Atanu Chakraborty
- Elza C. de Bruin
ArticleOpen Access17 Feb 2022 Scientific Reports
Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial
- Aleksandar Radosevic
- Rita Quesada
- Fernando Burdio
ArticleOpen Access10 Jan 2022 Scientific Reports
Tumor-infiltrating immune cell status predicts successful response to immune checkpoint inhibitors in renal cell carcinoma
- Akira Kazama
- Vladimir Bilim
- Yoshihiko Tomita
ArticleOpen Access27 Nov 2022 Scientific Reports
Activation of lysosomal mediated cell death in the course of autophagy by mTORC1 inhibitor
- Sameer Ullah Khan
- Anup Singh Pathania
- Fayaz Malik
ArticleOpen Access23 Mar 2022 Scientific Reports
Short- and long-term recurrence of early-stage invasive ductal carcinoma in middle-aged and old women with different treatments
- Yuan Kao
- Ying-Jhen Wu
- Chien-Cheng Huang
ArticleOpen Access15 Mar 2022 Scientific Reports
Synthetic correlated diffusion imaging hyperintensity delineates clinically significant prostate cancer
- Alexander Wong
- Hayden Gunraj
- Masoom A. Haider
ArticleOpen Access1 Mar 2022 Scientific Reports
Identification and validation of plasma biomarkers for diagnosis of breast cancer in South Asian women
- Thangarajan Rajkumar
- Sathyanarayanan Amritha
- Rajaraman Swaminathan
ArticleOpen Access7 Jan 2022 Scientific Reports
SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis
- Chunying Song
- Dong Liu
- Weikang Tao
ArticleOpen Access20 May 2022 Scientific Reports
Quantitative systems pharmacology modeling sheds light into the dose response relationship of a trispecific T cell engager in multiple myeloma
- R. E. Abrams
- K. Pierre
- S. K. Stamatelos
ArticleOpen Access29 Jun 2022 Scientific Reports
A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline
- Jianhui Bin
- Lieselotte Obst-Huebl
- Antoine M. Snijders
ArticleOpen Access27 Jan 2022 Scientific Reports
Tumor RNA transfected DCs derived from iPS cells elicit cytotoxicity against cancer cells induced from colorectal cancer patients in vitro
- Shimpei Maruoka
- Toshiyasu Ojima
- Hiroki Yamaue
ArticleOpen Access28 Feb 2022 Scientific Reports
Deep learning model for tongue cancer diagnosis using endoscopic images
- Jaesung Heo
- June Hyuck Lim
- Chul-Ho Kim
ArticleOpen Access15 Apr 2022 Scientific Reports
Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy
- Lipei Shao
- Avinash Iyer
- Ping Jin
ArticleOpen Access18 Feb 2022 Scientific Reports
Trends in female breast cancer incidence, mortality, and survival in Austria, with focus on age, stage, and birth cohorts (1983–2017)
- Lazo Ilic
- Gerald Haidinger
- Kyriaki Papantoniou
ArticleOpen Access29 Apr 2022 Scientific Reports
Biomarker dynamics and prognosis in breast cancer after neoadjuvant chemotherapy
- Cristina Zarotti
- Bärbel Papassotiropoulos
- Zsuzsanna Varga
ArticleOpen Access7 Jan 2022 Scientific Reports

51-75

Novel therapeutic strategy for melanoma based on albendazole and the CDK4/6 inhibitor palbociclib
- Lin Zhu
- Qin Yang
- Jing Liu
ArticleOpen Access5 Apr 2022 Scientific Reports
Association of hormone replacement therapy with risk of gastric cancer: a systematic review and meta-analysis
- Yeu-Chai Jang
- Chi Yan Leung
- Hsi-Lan Huang
ArticleOpen Access29 Jul 2022 Scientific Reports
Design of high avidity and low affinity antibodies for in situ control of antibody drug conjugate targeting
- Reginald Evans
- Greg M. Thurber
ArticleOpen Access10 May 2022 Scientific Reports
Prediction of lymph node metastasis in early colorectal cancer based on histologic images by artificial intelligence
- Manabu Takamatsu
- Noriko Yamamoto
- Kengo Takeuchi
ArticleOpen Access22 Feb 2022 Scientific Reports
Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney derangement in rats
- Solomon E. Owumi
- Abisola I. Kazeem
- Adegboyega K. Oyelere
ArticleOpen Access6 May 2022 Scientific Reports
Role of CD47 in tumor immunity: a potential target for combination therapy
- Jing Huang
- Fangkun Liu
- Yu Zeng
ArticleOpen Access13 Jun 2022 Scientific Reports
The prevalence of dental developmental anomalies among childhood cancer survivors according to types of anticancer treatment
- Elinor Halperson
- Vered Matalon
- Moti Moskovitz
ArticleOpen Access16 Mar 2022 Scientific Reports
The different overall survival between single-agent EGFR-TKI treatment and with bevacizumab in non-small cell lung cancer patients with brain metastasis
- Tzu-Hsuan Chiu
- Pi-Hung Tung
- Cheng-Ta Yang
ArticleOpen Access15 Mar 2022 Scientific Reports
Clinical characteristics, treatment, and prognosis of 118 cases of myeloid sarcoma
- Haiqiu Zhao
- Zhenkun Dong
- Rong Guo
ArticleOpen Access26 Apr 2022 Scientific Reports
Machine Learning analysis of high-grade serous ovarian cancer proteomic dataset reveals novel candidate biomarkers
- Federica Farinella
- Mario Merone
- Daniele Caligiore
ArticleOpen Access23 Feb 2022 Scientific Reports
Characterization of transcriptome diversity and in vitro behavior of primary human high-risk breast cells
- Sahar J. Alothman
- Keunsoo Kang
- Priscilla A. Furth
ArticleOpen Access22 Apr 2022 Scientific Reports
Detection of germline variants in Brazilian breast cancer patients using multigene panel testing
- Rodrigo Santa Cruz Guindalini
- Danilo Vilela Viana
- Maria Aparecida Azevedo Koike Folgueira
ArticleOpen Access9 Mar 2022 Scientific Reports
Deep learning for fully automatic detection, segmentation, and Gleason grade estimation of prostate cancer in multiparametric magnetic resonance images
- Oscar J. Pellicer-Valero
- José L. Marenco Jiménez
- José D. Martín-Guerrero
ArticleOpen Access22 Feb 2022 Scientific Reports
A deep learning-based radiomics approach to predict head and neck tumor regression for adaptive radiotherapy
- Shohei Tanaka
- Noriyuki Kadoya
- Keiichi Jingu
ArticleOpen Access27 May 2022 Scientific Reports
PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity
- Carolyn R. Maskin
- Renuka Raman
- Yariv Houvras
ArticleOpen Access2 Apr 2022 Scientific Reports
The impact of driver mutation on the treatment outcome of early-stage lung cancer patients receiving neoadjuvant immunotherapy and chemotherapy
- Po-Lan Su
- Jung-Yueh Chen
- Wu-Chou Su
ArticleOpen Access28 Feb 2022 Scientific Reports
cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer
- Ayano Kabashima
- Yuki Matsuo
- Shinji Tanaka
ArticleOpen Access30 Jun 2022 Scientific Reports
Gastric cancer cell death analyzed by live cell imaging of spheroids
- George Alzeeb
- Danielle Arzur
- Catherine Le Jossic-Corcos
ArticleOpen Access27 Jan 2022 Scientific Reports
Mass spectrometry imaging discriminates glioblastoma tumor cell subpopulations and different microvascular formations based on their lipid profiles
- Kelly C. O’Neill
- Evangelos Liapis
- Claire L. Carter
ArticleOpen Access12 Oct 2022 Scientific Reports
Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells
- Methi Wathikthinnakon
- Piriya Luangwattananun
- Aussara Panya
ArticleOpen Access13 Apr 2022 Scientific Reports
The third-generation anti-CD30 CAR T-cells specifically homing to the tumor and mediating powerful antitumor activity
- Shangkun Zhang
- Chaojiang Gu
- Tongcun Zhang
ArticleOpen Access21 Jun 2022 Scientific Reports
Follow-up of men with a PI-RADS 4/5 lesion after negative MRI/Ultrasound fusion biopsy
- Kira Kornienko
- Miriam Reuter
- Hannes Cash
ArticleOpen Access10 Aug 2022 Scientific Reports
Association between recurrent breast cancer and phthalate exposure modified by hormone receptors and body mass index
- Pei-Jing Yang
- Ming-Feng Hou
- Tsu-Nai Wang
ArticleOpen Access21 Feb 2022 Scientific Reports
Active surveillance versus initial surgery in the long-term management of Bosniak IIF–IV cystic renal masses
- Lassi Luomala
- Juhana Rautiola
- Harry Nisén
ArticleOpen Access17 Jun 2022 Scientific Reports
Survival prediction in triple negative breast cancer using multiple instance learning of histopathological images
- Piumi Sandarenu
- Ewan K. A. Millar
- Erik Meijering
ArticleOpen Access25 Aug 2022 Scientific Reports

76-100

Copy number alterations analysis of primary tumor tissue and circulating tumor cells from patients with early-stage triple negative breast cancer
- Marco Silvestri
- Matteo Dugo
- Vera Cappelletti
ArticleOpen Access27 Jan 2022 Scientific Reports
The K-Ras(G12D)-inhibitory peptide KS-58 suppresses growth of murine CT26 colorectal cancer cell-derived tumors
- Kotaro Sakamoto
- Bangzhong Lin
- Shinsaku Nakagawa
ArticleOpen Access17 May 2022 Scientific Reports
Targeting the translational machinery in gastrointestinal stromal tumors (GIST): a new therapeutic vulnerability
- Donna M. Lee
- Angela Sun
- Anette Duensing
ArticleOpen Access18 May 2022 Scientific Reports
Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas
- Wallax Augusto Silva Ferreira
- Glauco Akelinghton Freire Vitiello
- Edivaldo Herculano Correa de Oliveira
ArticleOpen Access19 Apr 2022 Scientific Reports
Impact of baseline culture conditions of cancer organoids when determining therapeutic response and tumor heterogeneity
- Rebecca A. DeStefanis
- Jeremy D. Kratz
- Dustin A. Deming
ArticleOpen Access25 Mar 2022 Scientific Reports
Microinvasive breast cancer and the role of sentinel lymph node biopsy
- Sean M. Hacking
- Kara-Lynne Leonard
- Yihong Wang
ArticleOpen Access20 Jul 2022 Scientific Reports
B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12
- Rae Hunter
- Kathleen J. Imbach
- Christopher C. Porter
ArticleOpen Access13 Jul 2022 Scientific Reports
Real-world evidence of the intrinsic limitations of PCR-based EGFR mutation assay in non-small cell lung cancer
- Chia-I Shen
- Chi-Lu Chiang
- Chao-Hua Chiu
ArticleOpen Access9 Aug 2022 Scientific Reports
Modelling liver cancer microenvironment using a novel 3D culture system
- Ala’a Al Hrout
- Karla Cervantes-Gracia
- Amr Amin
ArticleOpen Access14 May 2022 Scientific Reports
Role of CD68 in tumor immunity and prognosis prediction in pan-cancer
- Jingwei Zhang
- Shuwang Li
- Kui Yang
ArticleOpen Access12 May 2022 Scientific Reports
Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
- Natalia Maciejewska
- Mateusz Olszewski
- Maciej Baginski
ArticleOpen Access8 Mar 2022 Scientific Reports
Molecular investigation of possible relationships concerning bovine leukemia virus and breast cancer
- Zanib Khan
- Muhammad Abubakar
- Shumaila Manzoor
ArticleOpen Access9 Mar 2022 Scientific Reports
PD-L1 strong expressions affect the clinical outcomes of osimertinib in treatment naïve advanced EGFR-mutant non-small cell lung cancer patients
- Kuo-Hsuan Hsu
- Jeng-Sen Tseng
- Gee-Chen Chang
ArticleOpen Access13 Jun 2022 Scientific Reports
Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer
- Hidekazu Hirano
- Yuichi Abe
- Jun Adachi
ArticleOpen Access25 Mar 2022 Scientific Reports
The breast cancer immune microenvironment is modified by neoadjuvant chemotherapy
- Claudia Urueña
- Paola Lasso
- Susana Fiorentino
ArticleOpen Access13 May 2022 Scientific Reports
Identification of long non-coding RNAs and RNA binding proteins in breast cancer subtypes
- Claudia Cava
- Alexandros Armaos
- Isabella Castiglioni
ArticleOpen Access13 Jan 2022 Scientific Reports
Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS)
- Shirley Tong
- Maris A. Cinelli
- Sun Yang
ArticleOpen Access1 Feb 2022 Scientific Reports
Effects of inhalable gene transfection as a novel gene therapy for non-small cell lung cancer and malignant pleural mesothelioma
- Misa Ichikawa
- Naomi Muramatsu
- Akinobu Gotoh
ArticleOpen Access23 May 2022 Scientific Reports
Pressure increases PD-L1 expression in A549 lung adenocarcinoma cells and causes resistance to anti-ROR1 CAR T cell-mediated cytotoxicity
- Zhenglin Ou
- Xiaolin Dou
- Guodong Liu
ArticleOpen Access28 Apr 2022 Scientific Reports
Non-Helicobacter pylori Helicobacter (NHPH) positive gastric cancer
- Tomohiko Yasuda
- Hyun Seok Lee
- Sachiyo Nomura
ArticleOpen Access21 Mar 2022 Scientific Reports
Radiation dose enhancement using gold nanoparticles with a diamond linear accelerator target: a multiple cell type analysis
- Olivia Piccolo
- John D. Lincoln
- Michael N. Ha
ArticleOpen Access28 Jan 2022 Scientific Reports
Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors
- Yane Liu
- Duo Wang
- Qiong Yu
ArticleOpen Access8 Apr 2022 Scientific Reports
Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations
- Seyed Pairawan
- Argun Akcakanat
- Funda Meric-Bernstam
ArticleOpen Access24 Jan 2022 Scientific Reports
Outcomes of right-sided and left-sided colon cancer after curative resection
- Chien-Yi Yang
- Min-Hsuan Yen
- Tung-Cheng Chang
ArticleOpen Access5 Jul 2022 Scientific Reports
Conditioned media of pancreatic cancer cells and pancreatic stellate cells induce myeloid-derived suppressor cells differentiation and lymphocytes suppression
- Yuen Ping Chong
- Evelyn Priya Peter
- Ket Li Ho
ArticleOpen Access19 Jul 2022 Scientific Reports

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