Collection |

15th anniversary

November 2019 marks the 15th anniversary of the launch of Nature Reviews Gastroenterology & Hepatology (formerly published as Nature Clinical Practice Gastroenterology & Hepatology). To celebrate this occasion, we have delved into our archives to create a curated Collection of cutting-edge articles, historical pieces that still hold relevance today and thought-provoking commentaries and opinions. Featuring a range of article types, including Reviews, Consensus Statements and Comments, the Collection provides a snapshot of the gastroenterology and hepatology field over the past 15 years and a valuable resource encompassing basic, translational and clinical sciences.  

Cutting edge

This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies using molecular taxonomy to guide therapeutic development and therapy with the overall goal of improving outcomes for this disease.

Review Article | | Nature Reviews Gastroenterology & Hepatology

This Consensus Statement provides a conceptual and methodological framework to expand research on colonic motility in experimental animals and humans. The work is intended to facilitate the development of new drugs for common colonic motility disorders and of appropriate diagnostic and therapeutic algorithms for the management of paediatric and adult patients.

Consensus Statement | Open Access | | Nature Reviews Gastroenterology & Hepatology

The hepatic consequence of metabolic syndrome and obesity, nonalcoholic fatty liver disease (NAFLD), underlies many cases of hepatocellular carcinoma (HCC). In this Review, the authors discuss NAFLD-associated HCC, including its epidemiology, key features that promote hepatocarcinogenesis and the management of HCC in patients with obesity.

Review Article | | Nature Reviews Gastroenterology & Hepatology

Key hepatic functions are expressed non-uniformly across liver lobules, a phenomenon termed zonation. Here, Ben-Moshe and Itzkovitz discuss the principles of liver zonation, the intrinsic and extrinsic factors that dictate zonation patterns and new genomic approaches for studying zonation of parenchymal and non-parenchymal cells

Review Article | | Nature Reviews Gastroenterology & Hepatology

Cholangiocytes, which line the intrahepatic and extrahepatic bile ducts, are specialized cells that regulate bile production and homeostasis. Here, the authors discuss the role of cholangiocytes in development and liver regeneration, inflammation and fibrosis and their interactions with the immune system.

Review Article | | Nature Reviews Gastroenterology & Hepatology

Attention has turned to the gut microbiota in liver disease, including alcoholic and nonalcoholic fatty liver disease and hepatocellular carcinoma. This Review describes gut–liver communications, including evidence from animal and human studies, compares conditions within the liver disease spectrum and highlights key points for designing microbiome-based studies for liver disease research.

Review Article | | Nature Reviews Gastroenterology & Hepatology

The intestinal lymphatic vasculature has a range of functions, from maintenance of interstitial fluid balance to transport of antigens, cells, dietary lipids and fat-soluble vitamins. In this Review, Petrova and Bernier-Latmani provide an in-depth overview of intestinal lymphatics, including their roles in human diseases.

Review Article | | Nature Reviews Gastroenterology & Hepatology

Commentaries & opinion

Women physicians in gastroenterology and hepatology face unique challenges during their early careers, including implicit biases borne of ingrained gender stereotypes and the imposter syndrome. Addressing perceived biases and promoting leadership at the trainee level is crucial to improving female representation in gastroenterology and hepatology.

Comment | | Nature Reviews Gastroenterology & Hepatology

To deliver precision therapeutics, microbiome-based medicine will require precision of language, logic and numerical accuracy. Epidemiological lessons of the past suggest that attempts to link almost everything in modern life with the microbiome as a risk factor for disease, without rapprochement with plausible mechanisms, will generate controversy rather than consensus.

Comment | | Nature Reviews Gastroenterology & Hepatology

Late presentation to hepatitis B virus and hepatitis C virus care is common, hindering global efforts to reduce the morbidity and mortality associated with liver disease. Models of care promoting and simplifying early testing of viral hepatitis are needed if we are to eliminate viral hepatitis as a major public health threat by 2030.

Comment | | Nature Reviews Gastroenterology & Hepatology

In ulcerative colitis, treating beyond endoscopic healing has shown a reduction of relapse and hospitalization, pushing for histological remission to be embraced in clinical practice and clinical trials. Here, we propose the concept of disease clearance (symptomatic, endoscopic and histological remission) as the ultimate goal in the treatment of ulcerative colitis.

Comment | | Nature Reviews Gastroenterology & Hepatology

Important studies published in 2018 highlight novel therapeutic strategies along the disease course of IBD, including potential specific dietary modifications at early stages and treatment with adipose-derived stem cells in perianal Crohn’s disease. A treat-to-target approach that involves proactive serial monitoring of inflammatory biomarkers can assist in timely treatment escalation and promises improved patient outcomes.

Year in Review | | Nature Reviews Gastroenterology & Hepatology

Globally, alcohol is the biggest single preventable factor causing premature death and disability in adults aged 15–49 years. In this Perspective, Gilmore and colleagues summarize the evidence behind alcohol-related public health policies, including those targeting price, availability and marketing of alcohol, and assess their effectiveness.

Science and Society | | Nature Reviews Gastroenterology & Hepatology

The many gaps in our knowledge and understanding of HBV infection hampers our ability to develop and achieve a cure on a global scale. In this Perspective, Fabien Zoulim and colleagues propose the development of an international group consisting of four working groups (virology, immunology, innovative tools and clinical trials) to tackle the big questions and make important steps towards eradicating this disease.

Opinion | | Nature Reviews Gastroenterology & Hepatology

From the archive

In the past few years, data obtained from work in animal models, human genetics, basic science and clinical trials, has provided new insights into the mechanisms underlying Crohn's disease and ulcerative colitis. In this review, the author discusses the evidence underlying the disparate theories on the pathogenesis of these diseases and attempts to reconcile them into a coherent hypothesis based on the experimental data.

Review Article | | Nature Clinical Practice Gastroenterology & Hepatology

IBS is a major drain on health-care resources, partly because the pharmacological management of this condition is currently unsatisfactory. Cognitive behavioral therapy, psychotherapy and hypnotherapy can help by providing a global therapeutic approach for IBS. This Viewpoint article discusses the available evidence for these behavioral therapies and highlights the benefits and the difficulties of using such approaches.

Viewpoint | | Nature Reviews Gastroenterology & Hepatology

To practice evidence-based medicine, clinicians need to apply the findings of scientific research to the circumstances of individual patients as part of the process of clinical decision-making. This Review article presents a 10-step guide to the critical appraisal of research literature to assist clinicians with the task of identifying the most relevant, high-quality studies available to guide their practice.

Review Article | | Nature Clinical Practice Gastroenterology & Hepatology

The human gut harbours a vast array of micro-organisms and the benefits of these bacteria should not be forgotten. Here, Flint and colleagues discuss the role of the gut microbiota in nutrition and health, describing the development of these bacteria in the healthy gut, and their positive influences on microbial and human metabolism.

Review Article | | Nature Reviews Gastroenterology & Hepatology

Neurogastroenterology encompasses control of digestion through the enteric nervous system, the central nervous system and integrative centers in sympathetic ganglia. In this Review, John Furness provides a broad overview of the rapidly developing field of neurogastroenterology, with a focus on the roles of the enteric nervous system in the control of the musculature of the gastrointestinal tract and transmucosal fluid movement.

Review Article | | Nature Reviews Gastroenterology & Hepatology

Liver transplantation has progressed from an experimental procedure to routine operation since the first human liver transplantation in 1963. This Timeline article revisits the important milestones in the development of liver transplantation, discussing how the procedure has evolved over time and what challenges are still to overcome.

Timeline | | Nature Reviews Gastroenterology & Hepatology

Probiotics are widely regarded as live microorganisms that, when administered in sufficient amounts, confer a health benefit, but guidance is needed on the most appropriate use of the term. This Consensus Statement outlines recommendations for the scope and definition of the term 'probiotic' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in October 2013.

Consensus Statement | Open Access | | Nature Reviews Gastroenterology & Hepatology