Special Issue: Spatial Transcriptomics and Tumor Immune Microenvironment

The tumor microenvironment (TME) is a complex network of cells and extracellular components. It plays a crucial role in cancer development, progression, and treatment resistance. To develop effective cancer therapies, understanding the intricate interactions within the TME is essential. Spatial transcriptomics, a cutting-edge technique, has significantly enhanced our ability to analyze gene expression patterns in tissues. This technique provides valuable insights into the spatial diversity and cellular organization of the TME.

This issue aims to publish outstanding research and reviews on spatial transcriptomics in the TME, emphasizing its importance in cancer immune research and immunotherapy. We welcome submissions that use novel technologies, computational methods, and experimental approaches to understand spatial gene expression in the TME.

We aim to cover the following broad topics:

• Spatial Transcriptomic Technologies: Latest advancements and their application to studying the TME.
• Spatial Regulation of Immune Cells: Control of immune cell functions and implications for immunotherapy.
• Spatial Interactions: Crosstalk between tumor cells, immune cells, and other TME components.
• Spatial Heterogeneity and Tumor Evolution: Distribution and heterogeneity of cells in the TME and their impact.
• Spatial Transcriptomics in Precision Medicine: Potential in personalized cancer medicine strategies.

Keywords: Tumor Microenvironment (TME), Spatial Transcriptomics, Cancer Immunotherapy, Gene Expression Patterns, Immune Cell Regulation, Tumor-Immune Crosstalk, Cellular Heterogeneity, Tumor Evolution, Precision Medicine, Computational Methods, Experimental Approaches, Personalized Cancer Medicine Strategies