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Career Pathways Collection

The Career Pathways series features the stories of Nature Metabolism authors and their self-professed journeys to publication as young investigators. This Collection brings together the Career Pathway pieces and the original research published in Nature Metabolism by the authors.

Career Pathways

The transition from senior postdoc to early-stage investigator is a pivotal step in the careers of academic scientists. In this series, early-stage investigators reflect on their labs’ first publications and the journeys that led them there.

Viewpoint | | Nature Metabolism

In this instalment of Career pathways, we hear from Anja Zeigerer and Myriam Aouadi about how the support of institutions, labs and families can galvanize scientists’ passion and productivity.

Viewpoint | | Nature Metabolism

In this instalment of Career pathways, Jing Fan and Edward A. Phelps reflect on fostering their newly formed research programs in the face of challenges both familiar and new.

Viewpoint | | Nature Metabolism

Learning to balance work, family, optimism and setbacks is a process for all early-career investigators. Stephanie Correa and Leng Han share their stories in this instalment of Career pathways.

Viewpoint | | Nature Metabolism

In this instalment of Career pathways, Kivanç Birsoy and Sarah Lessard recount their roads to scientific research and reflect on how each step in their training prepared them for life as a group leader.

Viewpoint | | Nature Metabolism

In this instalment of Career pathways, James White and Wenjing Du reflect on the importance of recruiting the right people, staying excited and making work and home life coexist.

Viewpoint | | Nature Metabolism

Related Research

Glutamine is a major fuel for proliferating cells. Here the authors show that reduced dependence on exogenous glutamine is a generalizable feature of self-renewing pluripotent stem cells that can be exploited to select for mouse and human pluripotent stem cells with high self-renewal potential.

Letter | | Nature Metabolism

Creatine can be used for thermogenesis in adipocytes. Here Kazak et al. show that creatine uptake is required to sustain this thermogenic pathway. Knockdown of the creatine transporter, CrT, in adipocytes decreases thermogenesis and energy expenditure, whereas creatine supplementation increases energy expenditure in mice fed a high-fat diet.

Article | | Nature Metabolism

Proinflammatory activation of liver macrophages and their secretion of proinflammatory cytokines have been linked to obesity. Here Morgantini et al. report a mechanism through which liver macrophages can impair liver metabolism and promote insulin resistance in obesity in the absence of an overt proinflammatory phenotype, through secretion of non-inflammatory factors such as IGFBP7.

Article | | Nature Metabolism

Macrophages engage in a sequence of dynamic functional changes during immune responses. Here the authors elucidate a two-stage remodelling of the tricarboxylic acid cycle during this process, which is driven by regulation of the pyruvate dehydrogenase and the oxoglutarate dehydrogenase complexes, and causes transient accumulation of immunoregulatory metabolites.

Article | | Nature Metabolism

The ventromedial nucleus of the hypothalamus is known to maintain energy homeostasis by controlling locomotor activity and thermogenesis. Here van Veen and Kammel et al. identified heterogeneous neuronal populations with sexually dimorphic gene expression and functions by using single-cell RNA analysis.

Article | | Nature Metabolism