Cytokines are chemical cues that instruct the homeostasis and function of immune cells. Whereas proinflammatory cytokines alert the immune system to the presence of potential infection or danger, unregulated cytokine production can lead to autoinflammatory disease states. Nature Immunology presents four Reviews that discuss the regulation of type I interferons, the homeostatic cytokines IL-7 and TSLP and the inflammatory cytokine IL-17, and the implications of this for therapeutic intervention, as well as dysregulation that can lead to disease.



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