Mitochondria-Associated Membranes (MAMs) and pathologies

Mitochondria and endoplasmic reticulum (ER) play an essential role in cell physiology through the control of multiple signal transduction pathways. ER and mitochondria continuously exchange messages by a physical association between the two organelles called MAMs (Mitochondria-Associated Membranes). This communication plays a vital role in the cell fate because it has a dramatic consequence for the functioning of all the other intracellular compartments. In recent years, increasing evidence supports the notion that MAMs act as hotspot signaling domains and are deregulated in several human diseases.

In this special issue, the involvement of MAMs in important human pathologies is presented.