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Cancer at Nature Research

The Nature Research editors who handle cancer primary research, methods, protocols and reviews bring you the latest articles, covering all aspects from disease mechanisms to therapeutic approaches. Collected here you will also find specially curated content, such as collections, focus issues and animations, all ready to be used in presentations and educational materials. You can also find out about the editors handling cancer contents, and the journals at Nature Research that publish articles on this topic and how to submit to them.

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Research Articles

  • Nature Communications | Article | open

    Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.

    • David M. Gay
    • , Rachel A. Ridgway
    • , Miryam Müeller
    • , Michael C. Hodder
    • , Ann Hedley
    • , William Clark
    • , Joshua D. Leach
    • , Rene Jackstadt
    • , Colin Nixon
    • , David J. Huels
    • , Andrew D. Campbell
    • , Thomas G. Bird
    •  &  Owen J. Sansom
  • Nature Communications | Article | open

    BCL9 and Pygo are components of Wnt enhanceosome, which facilitates β-catenin-dependent transcription. Here, the authors show that deletion of Bcl9 and Pygo suppresses tumorigenesis and extends disease free survival in two different colorectal cancer models, suggesting a strategy for drugging β-catenin signalling in this cancer.

    • Juliusz Mieszczanek
    • , Laurens M. van Tienen
    • , Ashraf E. K. Ibrahim
    • , Douglas J. Winton
    •  &  Mariann Bienz
  • Nature Communications | Article | open

    Targeting histone acetylation modulators (HAMPs) is a promising avenue of drug discovery in cancer research. Here, the authors integrate multi-dimensional genomic profiles to systematically investigate recurrent genomic alterations in HAMPs, identifying potential therapeutic targets for precision epigenetic treatment.

    • Zhongyi Hu
    • , Junzhi Zhou
    • , Junjie Jiang
    • , Jiao Yuan
    • , Youyou Zhang
    • , Xuepeng Wei
    • , Nicki Loo
    • , Yueying Wang
    • , Yutian Pan
    • , Tianli Zhang
    • , Xiaomin Zhong
    • , Meixiao Long
    • , Kathleen T. Montone
    • , Janos L. Tanyi
    • , Yi Fan
    • , Tian-Li Wang
    • , Ie-Ming Shih
    • , Xiaowen Hu
    •  &  Lin Zhang
  • Nature Communications | Article | open

    Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pathological angiogenesis in this type of cancer.

    • Song Wu
    • , Tong Ou
    • , Nianzeng Xing
    • , Jiang Lu
    • , Shengqing Wan
    • , Changxi Wang
    • , Xi Zhang
    • , Feiya Yang
    • , Yi Huang
    •  &  Zhiming Cai
  • Nature Communications | Article | open

    Loss of PIK3R1 in ovarian cancer is a common event, which provides opportunities for therapeutic intervention. Here, the authors show that the STAT3 and AKT signaling pathways are activated upon PIK3R1 loss and that, in mice, inhibitors of these pathways could block tumorigenesis.

    • Xinran Li
    • , Victor C. Y. Mak
    • , Yuan Zhou
    • , Chao Wang
    • , Esther S. Y. Wong
    • , Rakesh Sharma
    • , Yiling Lu
    • , Annie N. Y. Cheung
    • , Gordon B. Mills
    •  &  Lydia W. T. Cheung
  • Nature Medicine | Letter

    Genomic, transcriptomic, and microenvironmental analyses of samples from patients with glioblastoma treated with nivolumab or pembrolizumab identifies features associated with treatment response that may help in refining patient stratification.

    • Junfei Zhao
    • , Andrew X. Chen
    • , Robyn D. Gartrell
    • , Andrew M. Silverman
    • , Luis Aparicio
    • , Tim Chu
    • , Darius Bordbar
    • , David Shan
    • , Jorge Samanamud
    • , Aayushi Mahajan
    • , Ioan Filip
    • , Rose Orenbuch
    • , Morgan Goetz
    • , Jonathan T. Yamaguchi
    • , Michael Cloney
    • , Craig Horbinski
    • , Rimas V. Lukas
    • , Jeffrey Raizer
    • , Ali I. Rae
    • , Jinzhou Yuan
    • , Peter Canoll
    • , Jeffrey N. Bruce
    • , Yvonne M. Saenger
    • , Peter Sims
    • , Fabio M. Iwamoto
    • , Adam M. Sonabend
    •  &  Raul Rabadan

Reviews

  • Nature Reviews Cancer | Review Article

    This Review discusses recent work demonstrating that immune checkpoint inhibitor efficacy is affected by a combination of factors involving tumour genomics, host germline genetics, programmed cell death 1 ligand 1 (PDL1) levels and other features of the tumour microenvironment, as well as the gut microbiome.

    • Jonathan J. Havel
    • , Diego Chowell
    •  &  Timothy A. Chan
  • Nature Metabolism | Review Article

    Like stem cells, cancer cells can rapidly proliferate but, unlike stem cells, they are mostly locked into a malignant identity. Here, Finley and Intlekofer highlight commonalities in anabolic pathways that support proliferation in cancer and stem cells, and point out unique metabolic features that influence self-renewal and differentiation.

    • Andrew M. Intlekofer
    •  &  Lydia W. S. Finley
  • Nature Reviews Disease Primers | Primer

    This Primer by Pfister and colleagues reviews the molecular genetics, diagnosis and management of medulloblastoma and touches upon the quality of life of patients and future outlooks.

    • Paul A. Northcott
    • , Giles W. Robinson
    • , Christian P. Kratz
    • , Donald J. Mabbott
    • , Scott L. Pomeroy
    • , Steven C. Clifford
    • , Stefan Rutkowski
    • , David W. Ellison
    • , David Malkin
    • , Michael D. Taylor
    • , Amar Gajjar
    •  &  Stefan M. Pfister

News & Commentary

  • Nature Reviews Cancer | Research Highlight

    Two phase I studies, recently published in Nature, show that the administration of personalized vaccines to newly diagnosed patients with glioblastoma generates tumour-reactive T cells that infiltrate glioblastomas, turning them into ‘hot’ tumours potentially susceptible to further immunotherapy approaches.

    • Maria Giuseppina Baratta
  • Nature Reviews Cancer | Research Highlight

    Two studies show that cancer cells contain sufficient quantities of immunostimulatory nucleic acids to trigger interferon signalling, increase antitumour immunity and overcome resistance to checkpoint blockade. Loss of the RNA-editing enzyme ADAR1 enables tumour cells to sense these innate ligands.

    • M. Teresa Villanueva
  • Nature Reviews Cancer | Research Highlight

    Gkountela et al. have identified that circulating tumour cell (CTC) clusters from patients and mouse models with breast cancer have a distinct DNA methylation profile from that of single CTCs, which together with the phenotypic difference represent a targetable therapeutic vulnerability of metastasis.

    • Anna Dart
  • Nature Reviews Immunology | Research Highlight

    A mix of 11 strains of commensal bacteria is shown to specifically induce potent antimicrobial and antitumour IFNγ-producing CD8+ T cells in mice.

    • Lucy Bird

Methods & Protocols

  • Nature Reviews Urology | News & Views

    Chronic inflammation in the prostate is a suspected risk factor for prostate cancer. Burns and colleagues implicate chronic inflammation in prostate cancer development, albeit from an unexpected source — the gastrointestinal tract. This new study implicates a history of inflammatory bowel disease with an increased risk of a prostate cancer diagnosis.

    • Karen S. Sfanos
    •  &  Corinne E. Joshu
  • Nature Genetics | Analysis

    This comprehensive pancancer analysis of RNA-sequencing data from bulk tumors defines the landscape of tumor-infiltrating B cell–receptor repertoires and highlights new mechanisms of tumor immune evasion through genetic alterations.

    • Xihao Hu
    • , Jian Zhang
    • , Jin Wang
    • , Jingxin Fu
    • , Taiwen Li
    • , Xiaoqi Zheng
    • , Binbin Wang
    • , Shengqing Gu
    • , Peng Jiang
    • , Jingyu Fan
    • , Xiaomin Ying
    • , Jing Zhang
    • , Michael C. Carroll
    • , Kai W. Wucherpfennig
    • , Nir Hacohen
    • , Fan Zhang
    • , Peng Zhang
    • , Jun S. Liu
    • , Bo Li
    •  &  X. Shirley Liu