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Nature Insight: DNA replication and repair
Vol. 447, No. 7147 pp 923-958
Organisms need to preserve genetic information to prevent the detrimental effects of ageing and disease. This is achieved by accurate replication of DNA and by repair of any damage incurred as a consequence of endogenous or exogenous factors. Researchers are now uncovering exciting details about DNA replication and repair. These processes are proving to be highly interconnected, and new insights could lead to treatments for various diseases and age-related disorders.
Editorial
DNA replication and repair
Angela K. Eggleston
doi:10.1038/447923a
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Reviews
Replication and protection of telomeres
Ramiro E. Verdun & Jan Karlseder
doi:10.1038/nature05976
Abstract | Full Text | PDF (704KB)
Expandable DNA repeats and human disease
Sergei M. Mirkin
doi:10.1038/nature05977
Abstract | Full Text | PDF (644KB)
Base-excision repair of oxidative DNA damage
Sheila S. David, Valerie L. O'Shea & Sucharita Kundu
doi:10.1038/nature05978
Abstract | Full Text | PDF (1,003KB)
Chromatin dynamics and the preservation of genetic information
Jessica A. Downs, Michel C. Nussenzweig & André Nussenzweig
doi:10.1038/nature05980
Abstract | Full Text | PDF (893KB)
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