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Recent advances in understanding inflammation

Uncontrolled inflammation can lead to chronic diseases since cells of the immune system, but also epithelial and endothelial cells, become inadequately activated producing cytokines, chemokines and lipid mediators. The immunopathology of chronic inflammatory diseases involves cell death, particularly in cells of epithelial origin, resulting in tissue damage and organ dysfunction. In recent years, many targeted therapies have been developed that have led to significant progress in the treatment of allergic and autoimmune diseases.

In this special issue, novel aspects of the pathophysiology of inflammation, including the regulation of pyroptosis and necroptosis, barrier function, and innate immunity, are presented.