Endocrine disruption

Endocrine-disrupting chemicals (EDCs) are a class of chemicals that mimic, block or interfere with the production, metabolism or action of hormones in the body. As EDCs are ubiquitous in our environment, food and consumer products, they pose a threat not just to public health but to global health. This Nature Reviews Endocrinology web collection on endocrine disruption contains Reviews and commentaries written by leading researchers in the field, as well as key advances in EDC research highlighted by journal editors. The collection covers the biological effects of EDCs and evidence linking EDC exposures to adverse health outcomes such as obesity, diabetes mellitus, nonalcoholic fatty liver disease, male and female reproductive disorders, neurodevelopmental disorders, asthma and cancer, together with emerging technologies that have the potential to characterize current and past EDC exposures and predict risk of developing EDC-related diseases in the future.

Reviews & Perspectives

  • Nature Reviews Endocrinology | Opinion

    The emerging field of omics has the potential to advance and strengthen research into endocrine-disrupting chemicals (EDCs). In this Opinion article, Andrea Baccarelli and colleagues discuss the potential of using omics technologies — both established and developing — to characterize present and past EDC exposures and predict risk of developing EDC-related diseases.

    • Carmen Messerlian
    • , Rosie M. Martinez
    • , Russ Hauser
    •  &  Andrea A. Baccarelli
  • Nature Reviews Endocrinology | Review

    Metabolism-disrupting chemicals (MDCs) are a subclass of endocrine-disrupting chemicals that affect energy homeostasis. Here, Angel Nadal and colleagues review the main mechanisms used by MDCs to alter energy balance, information that should help to identify new MDCs, as well as novel targets of their action.

    • Angel Nadal
    • , Ivan Quesada
    • , Eva Tudurí
    • , Rubén Nogueiras
    •  &  Paloma Alonso-Magdalena
  • Nature Reviews Endocrinology | Review

    In this Review, Foulds et al. posit that endocrine-disrupting chemicals are an unappreciated driver of the development and progression of nonalcoholic fatty liver disease. Experimental animal studies supporting this association are discussed, together with the challenges of establishing a causal link in humans.

    • Charles E. Foulds
    • , Lindsey S. Treviño
    • , Brian York
    •  &  Cheryl L. Walker
  • Nature Reviews Endocrinology | Review

    Evidence suggests that early-life exposure to endocrine-disrupting chemicals might contribute to the development of reproductive disorders. Here, Julie Boberg and colleagues summarize the current knowledge of how environmental chemicals and pharmaceuticals potentially contribute to the development of ovarian dysgenesis syndrome.

    • Hanna Katarina Lilith Johansson
    • , Terje Svingen
    • , Paul A. Fowler
    • , Anne Marie Vinggaard
    •  &  Julie Boberg
  • Nature Reviews Endocrinology | Review

    Endocrine-disrupting chemicals (EDCs) can increase the risk of childhood diseases by disrupting hormone-mediated processes critical for growth and development. Here, Joseph Braun discusses epidemiological evidence of associations between early-life exposure to EDCs and childhood neurodevelopmental disorders and obesity.

    • Joseph M. Braun
  • Nature Reviews Endocrinology | Review

    Concern exists about the possible link between intrauterine exposure to analgesics and congenital malformations. Here, Bernard Jégou and colleagues discuss the effects of mild analgesics (paracetamol and NSAIDs) on endocrine homeostasis and the reproductive system in animals and humans of both sexes, from fetal life to adulthood.

    • David M. Kristensen
    • , Séverine Mazaud-Guittot
    • , Pierre Gaudriault
    • , Laurianne Lesné
    • , Tania Serrano
    • , Katharina M. Main
    •  &  Bernard Jégou

News & Comment

Research Highlights