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Endocrine-disrupting chemicals (EDCs) are a class of chemicals that mimic, block or interfere with the production, metabolism or action of hormones in the body. As EDCs are ubiquitous in our environment, food and consumer products, they pose a threat not just to public health but to global health. This Nature Reviews Endocrinologyweb collection on endocrine disruption contains Reviews and commentaries written by leading researchers in the field, as well as key advances in EDC research highlighted by journal editors. The collection covers the biological effects of EDCs and evidence linking EDC exposures to adverse health outcomes such as obesity, diabetes mellitus, nonalcoholic fatty liver disease, male and female reproductive disorders, neurodevelopmental disorders, asthma and cancer, together with emerging technologies that have the potential to characterize current and past EDC exposures and predict risk of developing EDC-related diseases in the future.