Scientific Reports

Collection 12 March 2023

Top 100 in Cell and Molecular Biology - 2022

This collection highlights our most downloaded* cell and molecular biology papers published in 2022. Featuring authors from around the world, these papers showcase valuable research from an international community.

You can also view the top papers across various subject areas here.

*Data obtained from SN Insights, which is based on Digital Science's Dimensions.

1-25

HS3ST2 expression induces the cell autonomous aggregation of tau
- M. B. Huynh
- N. Rebergue
- D. Papy-Garcia
ArticleOpen Access27 Jun 2022 Scientific Reports
Therapeutic enzyme engineering using a generative neural network
- Andrew Giessel
- Athanasios Dousis
- Stuart Licht
ArticleOpen Access27 Jan 2022 Scientific Reports
Cinnamon extract improves abnormalities in glucose tolerance by decreasing Acyl-CoA synthetase long-chain family 1 expression in adipocytes
- Tsubame Nishikai-Shen
- Tomomi Hosono-Fukao
- Taiichiro Seki
ArticleOpen Access22 Jul 2022 Scientific Reports
Different methods of detaching adherent cells and their effects on the cell surface expression of Fas receptor and Fas ligand
- Ting-Yu Lai
- Jerry Cao
- Chih-Yuan Lee
ArticleOpen Access5 Apr 2022 Scientific Reports
Folic acid depletion as well as oversupplementation helps in the progression of hepatocarcinogenesis in HepG2 cells
- Renuka Sharma
- Taqveema Ali
- Jyotdeep Kaur
ArticleOpen Access5 Oct 2022 Scientific Reports
Machine learning/molecular dynamic protein structure prediction approach to investigate the protein conformational ensemble
- Martina Audagnotto
- Werngard Czechtizky
- Johan Ulander
ArticleOpen Access15 Jun 2022 Scientific Reports
LIM Tracker: a software package for cell tracking and analysis with advanced interactivity
- Hideya Aragaki
- Katsunori Ogoh
- Kazuhiro Aoki
ArticleOpen Access17 Feb 2022 Scientific Reports
Anti-nucleocapsid antibodies enhance the production of IL-6 induced by SARS-CoV-2 N protein
- Emi E. Nakayama
- Ritsuko Kubota-Koketsu
- Tatsuo Shioda
ArticleOpen Access16 May 2022 Scientific Reports
Prediction of protein–protein interaction using graph neural networks
- Kanchan Jha
- Sriparna Saha
- Hiteshi Singh
ArticleOpen Access19 May 2022 Scientific Reports
Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
- Rocío Gallego-Durán
- Javier Ampuero
- Manuel Romero-Gómez
ArticleOpen Access1 Mar 2022 Scientific Reports
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
- Hao-Bo Guo
- Alexander Perminov
- Rajiv Berry
ArticleOpen Access23 Jun 2022 Scientific Reports
Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
- Gregory S. McElroy
- Ram P. Chakrabarty
- Navdeep S. Chandel
ArticleOpen Access25 Mar 2022 Scientific Reports
LM-GVP: an extensible sequence and structure informed deep learning framework for protein property prediction
- Zichen Wang
- Steven A. Combs
- Peter M. Clark
ArticleOpen Access27 Apr 2022 Scientific Reports
Optimization of methods for the accurate characterization of whole blood neutrophils
- Ashley N. Connelly
- Richard P. H. Huijbregts
- Zdenek Hel
ArticleOpen Access7 Mar 2022 Scientific Reports
Confocal microscopy analysis reveals that only a small proportion of extracellular vesicles are successfully labelled with commonly utilised staining methods
- Genevieve E. Melling
- Ross Conlon
- David R. F. Carter
ArticleOpen Access7 Jan 2022 Scientific Reports
Endothelial inflammation and neutrophil transmigration are modulated by extracellular matrix composition in an inflammation-on-a-chip model
- Rebecca B. Riddle
- Karin Jennbacken
- Matthew T. Harper
ArticleOpen Access27 Apr 2022 Scientific Reports
Engineering and validation of a dual luciferase reporter system for quantitative and systematic assessment of regulatory sequences in Chinese hamster ovary cells
- Yagmur Toktay
- Bengisu Dayanc
- Serif Senturk
ArticleOpen Access11 Apr 2022 Scientific Reports
Capsaicin directly promotes adipocyte browning in the chemical compound-induced brown adipocytes converted from human dermal fibroblasts
- Yukimasa Takeda
- Ping Dai
ArticleOpen Access22 Apr 2022 Scientific Reports
Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway
- Oluwafemi Adeleke Ojo
- Jennifer Chidubem Amanze
- Adebola Busola Ojo
ArticleOpen Access21 Feb 2022 Scientific Reports
Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein
- Lasse Reimer
- Caroline Haikal
- Poul Henning Jensen
ArticleOpen Access8 Mar 2022 Scientific Reports
Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden
- Celia A. McKee
- Jiyeon Lee
- Erik S. Musiek
ArticleOpen Access2 Feb 2022 Scientific Reports
Dual-expression system for blue fluorescent protein optimization
- Stavrini Papadaki
- Xinyue Wang
- Kiryl D. Piatkevich
ArticleOpen Access17 Jun 2022 Scientific Reports
Design and simulation of the liposomal model by using a coarse-grained molecular dynamics approach towards drug delivery goals
- Jalil Parchekani
- Abdollah Allahverdi
- Hossein Naderi-Manesh
ArticleOpen Access11 Feb 2022 Scientific Reports
Metabolites of soil microorganisms modulate amyloid β production in Alzheimer’s neurons
- Takayuki Kondo
- Tsuyoshi Yamamoto
- Haruhisa Inoue
ArticleOpen Access2 Mar 2022 Scientific Reports
Transposase-CRISPR mediated targeted integration (TransCRISTI) in the human genome
- Mahere Rezazade Bazaz
- Mohammad M. Ghahramani Seno
- Hesam Dehghani
ArticleOpen Access1 Mar 2022 Scientific Reports

26-50

Super-resolution visualization of chromatin loop folding in human lymphoblastoid cells using interferometric photoactivated localization microscopy
- Zofia Parteka-Tojek
- Jacqueline Jufen Zhu
- Yijun Ruan
ArticleOpen Access20 May 2022 Scientific Reports
Integrated bioinformatics and network pharmacology to identify the therapeutic target and molecular mechanisms of Huangqin decoction on ulcerative Colitis
- Yi Wu
- Xinqiao Liu
- Guiwei Li
ArticleOpen Access7 Jan 2022 Scientific Reports
Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body
- Shiori Awa
- Genjiro Suzuki
- Masato Hasegawa
ArticleOpen Access21 Jan 2022 Scientific Reports
Metformin alleviates neurocognitive impairment in aging via activation of AMPK/BDNF/PI3K pathway
- Omnia Ameen
- Rehab M. Samaka
- Reda A. A. Abo-Elsoud
ArticleOpen Access12 Oct 2022 Scientific Reports
Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia
- Sam J. Washer
- Marta Perez-Alcantara
- Sally A. Cowley
ArticleOpen Access14 Nov 2022 Scientific Reports
A mechanistic view on the aging human skin through ex vivo layer-by-layer analysis of mechanics and microstructure of facial and mammary dermis
- Barbara Lynch
- Hervé Pageon
- Yegor Domanov
ArticleOpen Access17 Jan 2022 Scientific Reports
Effect of substrate stiffness on friction in collective cell migration
- Kelly Vazquez
- Aashrith Saraswathibhatla
- Jacob Notbohm
ArticleOpen Access15 Feb 2022 Scientific Reports
Label-free imaging flow cytometry for analysis and sorting of enzymatically dissociated tissues
- Maik Herbig
- Karen Tessmer
- Marius Ader
ArticleOpen Access19 Jan 2022 Scientific Reports
Near-infrared light reduces glia activation and modulates neuroinflammation in the brains of diet-induced obese mice
- Salvatore Saieva
- Giulio Taglialatela
ArticleOpen Access27 Jun 2022 Scientific Reports
Identification of candidate biomarkers and pathways associated with type 1 diabetes mellitus using bioinformatics analysis
- Madhu Pujar
- Basavaraj Vastrad
- Shivakumar Kotturshetti
ArticleOpen Access1 Jun 2022 Scientific Reports
Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs)
- M. Meltzer
- T. Zvagelsky
- Stanislav Engel
ArticleOpen Access23 May 2022 Scientific Reports
Antiproliferative effects of AAV-delivered CRISPR/Cas9-based degradation of the HPV18-E6 gene in HeLa cells
- Zahra Noroozi
- Mehdi Shamsara
- Mohammad Hossein Modarressi
ArticleOpen Access9 Feb 2022 Scientific Reports
Site-specific CRISPR-based mitochondrial DNA manipulation is limited by gRNA import
- Ludwig Schmiderer
- David Yudovich
- Jonas Larsson
ArticleOpen Access4 Nov 2022 Scientific Reports
A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer’s disease
- Elena Ficulle
- Sarubini Kananathan
- Suchira Bose
ArticleOpen Access17 Feb 2022 Scientific Reports
MALAT1 as master regulator of biomarkers predictive of pan-cancer multi-drug resistance in the context of recalcitrant NRAS signaling pathway identified using systems-oriented approach
- Santosh Kumar
- Seema Mishra
ArticleOpen Access9 May 2022 Scientific Reports
Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation
- Shan-Shan Xie
- Yan Deng
- Wei-Fang Lan
ArticleOpen Access23 Feb 2022 Scientific Reports
Extracellular degradation of a polyurethane oligomer involving outer membrane vesicles and further insights on the degradation of 2,4-diaminotoluene in Pseudomonas capeferrum TDA1
- Òscar Puiggené
- María José Cárdenas Espinosa
- Christian Eberlein
ArticleOpen Access17 Feb 2022 Scientific Reports
Phosphate-regulated expression of the SARS-CoV-2 receptor-binding domain in the diatom Phaeodactylum tricornutum for pandemic diagnostics
- Samuel S. Slattery
- Daniel J. Giguere
- David R. Edgell
ArticleOpen Access29 Apr 2022 Scientific Reports
A specific hybridisation internalisation probe (SHIP) enables precise live-cell and super-resolution imaging of internalized cargo
- Sara Hernández-Pérez
- Pieta K. Mattila
ArticleOpen Access12 Jan 2022 Scientific Reports
A pro-oxidant combination of resveratrol and copper down-regulates multiple biological hallmarks of ageing and neurodegeneration in mice
- Kavita Pal
- Gorantla V. Raghuram
- Indraneel Mittra
ArticleOpen Access14 Oct 2022 Scientific Reports
Confrontation of AlphaFold models with experimental structures enlightens conformational dynamics supporting CYP102A1 functions
- Philippe Urban
- Denis Pompon
ArticleOpen Access25 Sep 2022 Scientific Reports
Altered mitochondrial microenvironment at the spotlight of musculoskeletal aging and Alzheimer’s disease
- Panagiotis Giannos
- Konstantinos Prokopidis
- Mathew Hill
ArticleOpen Access4 Jul 2022 Scientific Reports
Investigation and validation of labelling loop mediated isothermal amplification (LAMP) products with different nucleotide modifications for various downstream analysis
- Christian Warmt
- Ceren Yaslanmaz
- Jörg Henkel
ArticleOpen Access3 May 2022 Scientific Reports
Irreversible alteration of extracellular vesicle and cell-free messenger RNA profiles in human plasma associated with blood processing and storage
- Hyun Ji Kim
- Matthew J. Rames
- Thuy T. M. Ngo
ArticleOpen Access8 Feb 2022 Scientific Reports
Bioinformatic analyses to uncover genes involved in trehalose metabolism in the polyploid sugarcane
- Lauana Pereira de Oliveira
- Bruno Viana Navarro
- Marcos Silveira Buckeridge
ArticleOpen Access7 May 2022 Scientific Reports

51-75

Tofacitinib and metformin reduce the dermal thickness and fibrosis in mouse model of systemic sclerosis
- Ahmet Karatas
- Burak Oz
- Suleyman Serdar Koca
ArticleOpen Access15 Feb 2022 Scientific Reports
Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
- Laura Torres-Garcia
- Joana M. P. Domingues
- Jia-Yi Li
ArticleOpen Access22 Feb 2022 Scientific Reports
Functional buffering via cell-specific gene expression promotes tissue homeostasis and cancer robustness
- Hao-Kuen Lin
- Jen-Hao Cheng
- Sheng-hong Chen
ArticleOpen Access22 Feb 2022 Scientific Reports
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology
- Liberty François-Moutal
- David Donald Scott
- May Khanna
ArticleOpen Access17 May 2022 Scientific Reports
Rational peptide design for regulating liquid–liquid phase separation on the basis of residue–residue contact energy
- Kiyoto Kamagata
- Maulana Ariefai
- Tomoshi Kameda
ArticleOpen Access12 Aug 2022 Scientific Reports
Effective prediction of short hydrogen bonds in proteins via machine learning method
- Shengmin Zhou
- Yuanhao Liu
- Lu Wang
ArticleOpen Access10 Jan 2022 Scientific Reports
Modeling axonal regeneration by changing cytoskeletal dynamics in stem cell-derived motor nerve organoids
- Woo Min Seo
- Jiyoung Yoon
- Mi-Ryoung Song
ArticleOpen Access8 Feb 2022 Scientific Reports
Amyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer’s disease experimental models
- Macarena de la Cueva
- Desiree Antequera
- Fernando Bartolome
ArticleOpen Access16 Jun 2022 Scientific Reports
Improving the differentiation potential of pluripotent stem cells by optimizing culture conditions
- Takako Yamamoto
- Mao Arita
- Shin Kawamata
ArticleOpen Access19 Aug 2022 Scientific Reports
GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems
- Cristina V. Iancu
- Giovanni Bocci
- Jun-yong Choe
ArticleOpen Access26 Jan 2022 Scientific Reports
Extracting phylogenetic dimensions of coevolution reveals hidden functional signals
- Alexandre Colavin
- Esha Atolia
- Kerwyn Casey Huang
ArticleOpen Access17 Jan 2022 Scientific Reports
Plasma protein biomarker model for screening Alzheimer disease using multiple reaction monitoring-mass spectrometry
- Yeongshin Kim
- Jaenyeon Kim
- Youngsoo Kim
ArticleOpen Access24 Jan 2022 Scientific Reports
Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules
- Junpei Sanada
- Atsushi Obata
- Hideaki Kaneto
ArticleOpen Access2 Aug 2022 Scientific Reports
A role for the periplasmic adaptor protein AcrA in vetting substrate access to the RND efflux transporter AcrB
- Ilyas Alav
- Vassiliy N. Bavro
- Jessica M. A. Blair
ArticleOpen Access19 Mar 2022 Scientific Reports
Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease
- Arundhati Jana
- Xinge Wang
- Jalees Rehman
ArticleOpen Access1 Oct 2022 Scientific Reports
The anti-inflammatory effects of Akkermansia muciniphila and its derivates in HFD/CCL4-induced murine model of liver injury
- Shahrbanoo Keshavarz Azizi Raftar
- Fatemeh Ashrafian
- Mohammad Reza Zali
ArticleOpen Access14 Feb 2022 Scientific Reports
High-throughput formation and image-based analysis of basal-in mammary organoids in 384-well plates
- Soojung Lee
- Jonathan Chang
- Shuichi Takayama
ArticleOpen Access10 Jan 2022 Scientific Reports
Aptamer loaded superparamagnetic beads for selective capturing and gentle release of activated protein C
- Nasim Shahidi Hamedani
- Felix Lucian Happich
- Bernd Pötzsch
ArticleOpen Access30 Apr 2022 Scientific Reports
Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons
- Alessandro Soloperto
- Deborah Quaglio
- Alberto Boffi
ArticleOpen Access28 Mar 2022 Scientific Reports
A small molecule high throughput screening platform to profile conformational properties of nascent, ribosome-bound proteins
- Hideki Shishido
- Jae Seok Yoon
- William R. Skach
ArticleOpen Access15 Feb 2022 Scientific Reports
Hippocampal representations for deep learning on Alzheimer’s disease
- Ignacio Sarasua
- Sebastian Pölsterl
- Christian Wachinger
ArticleOpen Access21 May 2022 Scientific Reports
Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC
- Hideyuki Hiyoshi
- Kensuke Sakuma
- Taro Toyoda
ArticleOpen Access18 Mar 2022 Scientific Reports
A combination of multiple autoantibodies is associated with the risk of Alzheimer’s disease and cognitive impairment
- Sung-Mi Shim
- Young Ho Koh
- Jae-Pil Jeon
ArticleOpen Access25 Jan 2022 Scientific Reports
Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4⁺ T cell
- Louise S. Matheson
- Georg Petkau
- Martin Turner
ArticleOpen Access16 Nov 2022 Scientific Reports
Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells
- Masayoshi Suda
- Ippei Shimizu
- Tohru Minamino
ArticleOpen Access20 Apr 2022 Scientific Reports

76-100

Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration
- Sounak Sahu
- Mary E. Albaugh
- Shyam K. Sharan
ArticleOpen Access3 May 2022 Scientific Reports
PPE51 mediates uptake of trehalose across the mycomembrane of Mycobacterium tuberculosis
- Mohammed Rizwan Babu Sait
- Hendrik Koliwer-Brandl
- Rainer Kalscheuer
ArticleOpen Access8 Feb 2022 Scientific Reports
Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control
- Nikolas Zeh
- Melina Bräuer
- Kerstin Otte
ArticleOpen Access10 Feb 2022 Scientific Reports
A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment
- Daniel M. Tremmel
- Sara Dutton Sackett
- Jon S. Odorico
ArticleOpen Access3 May 2022 Scientific Reports
Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site
- Eric R. Goedken
- Maria A. Argiriadi
- Chaohong Sun
ArticleOpen Access26 Aug 2022 Scientific Reports
Simultaneous expansion microscopy imaging of proteins and mRNAs via dual-ExM
- In Cho
- Jae-Byum Chang
ArticleOpen Access1 Mar 2022 Scientific Reports
Analytical method validation for assay determination of cannabidiol and tetrahydrocannabinol in hemp oil infused products by RP-HPLC
- Sandhyarani Analakkattillam
- Victor K. Langsi
- Eric Moore
ArticleOpen Access21 Jul 2022 Scientific Reports
Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy
- Guilherme Pedron Formigari
- Marcella Neves Dátilo
- José B. Lopes de Faria
ArticleOpen Access31 May 2022 Scientific Reports
Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
- Sven Ruf
- Sridharan Rajagopal
- Aimo Kannt
ArticleOpen Access14 Sep 2022 Scientific Reports
Fibroblast-mediated uncaging of cancer cells and dynamic evolution of the physical microenvironment
- Chang Liu
- Michael Mak
ArticleOpen Access17 Jan 2022 Scientific Reports
Proteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids
- Abigail C. Buenafe
- Craig Dorrell
- Daniel L. Marks
ArticleOpen Access3 Mar 2022 Scientific Reports
Membrane rigidity regulates E. coli proliferation rates
- Samuel Salinas-Almaguer
- Michael Mell
- Francisco Monroy
ArticleOpen Access18 Jan 2022 Scientific Reports
A coordinate-based co-localization index to quantify and visualize spatial associations in single-molecule localization microscopy
- Jelmer Willems
- Harold D. MacGillavry
ArticleOpen Access18 Mar 2022 Scientific Reports
Magnesium rescues the morphology of Bacillus subtilis mreB mutants through its inhibitory effect on peptidoglycan hydrolases
- Benoit Tesson
- Alex Dajkovic
- Rut Carballido-López
ArticleOpen Access21 Jan 2022 Scientific Reports
Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
- Ying Li
- Chad Lamar Talbot
- Bhagirath Chaurasia
ArticleOpen Access4 May 2022 Scientific Reports
Urolithin A attenuates auditory cell senescence by activating mitophagy
- Sung Il Cho
- Eu-Ri Jo
- Hansoo Song
ArticleOpen Access11 May 2022 Scientific Reports
Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function
- Fumie Mitani
- Jianyu Lin
- Chitose Oneyama
ArticleOpen Access23 Apr 2022 Scientific Reports
Multiscale entropy analysis of retinal signals reveals reduced complexity in a mouse model of Alzheimer’s disease
- Joaquín Araya-Arriagada
- Sebastián Garay
- Leonel E. Medina
ArticleOpen Access25 May 2022 Scientific Reports
Cell surface detection of vimentin, ACE2 and SARS-CoV-2 Spike proteins reveals selective colocalization at primary cilia
- Vasiliki Lalioti
- Silvia González-Sanz
- Dolores Pérez-Sala
ArticleOpen Access29 Apr 2022 Scientific Reports
Stimulated emission depletion microscopy with a single depletion laser using five fluorochromes and fluorescence lifetime phasor separation
- Mariano Gonzalez Pisfil
- Iliya Nadelson
- Steffen Dietzel
ArticleOpen Access18 Aug 2022 Scientific Reports
Cell-free protein crystallization for nanocrystal structure determination
- Satoshi Abe
- Junko Tanaka
- Takafumi Ueno
ArticleOpen Access3 Oct 2022 Scientific Reports
Matrix stiffness and architecture drive fibro-adipogenic progenitors’ activation into myofibroblasts
- Taryn Loomis
- Lin-Ya Hu
- Lucas R. Smith
ArticleOpen Access9 Aug 2022 Scientific Reports
Dual detection high-speed capillary electrophoresis for simultaneous serum protein analysis and immunoassays
- Prabhavie M. Opallage
- Miyuru De Silva
- Robert C. Dunn
ArticleOpen Access4 Feb 2022 Scientific Reports
CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor
- Shorouk El Sayed
- Izabel Patik
- Bruce H. Horwitz
ArticleOpen Access10 Jan 2022 Scientific Reports
P2X₄ deficiency reduces atherosclerosis and plaque inflammation in mice
- Alexander Peikert
- Sebastian König
- Peter Stachon
ArticleOpen Access18 Feb 2022 Scientific Reports

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