British Journal of Cancer

Series 19 April 2021

Cellular and Molecular Biology

The Cellular and Molecular Biology subject category is edited by Professor Margaret Ashcroft (Cambridge, UK).

This subject category considers studies that provide novel insight into basic cellular and molecular mechanisms of cancer, that are clinically and/or therapeutically relevant.

See below for the latest research from this subject category

Articles

Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells
- Yihe Yan
- Leting Zheng
- David A. Geller
Article26 Mar 2021 British Journal of Cancer
The amino acid metabolism is essential for evading physical plasma-induced tumour cell death
- Rajesh Kumar Gandhirajan
- Dorothee Meyer
- Sander Bekeschus
ArticleOpen Access25 Mar 2021 British Journal of Cancer
RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway
- Omprakash Shriwas
- Rakesh Arya
- Rupesh Dash
Article24 Mar 2021 British Journal of Cancer
PI3K activation promotes resistance to eribulin in HER2-negative breast cancer
- Albert Gris-Oliver
- Yasir H. Ibrahim
- Violeta Serra
Article15 Mar 2021 British Journal of Cancer
Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis
- Chenran Wang
- Michael A. Haas
- Jun-Lin Guan
Article15 Mar 2021 British Journal of Cancer
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours
- Silpa Gampala
- Fenil Shah
- Melissa L. Fishel
ArticleOpen Access3 Mar 2021 British Journal of Cancer
CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner
- Wanli Zhai
- Xiongjun Ye
- Zhijie Chang
ArticleOpen Access3 Feb 2021 British Journal of Cancer
Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53–Bcl-2 intrinsic apoptosis pathway
- Takashi Miwa
- Mitsuro Kanda
- Yasuhiro Kodera
ArticleOpen Access3 Feb 2021 British Journal of Cancer
EEF1A2 interacts with HSP90AB1 to promote lung adenocarcinoma metastasis via enhancing TGF-β/SMAD signalling
- Liqing Jia
- Xiaolu Ge
- Zheng Li
ArticleOpen Access21 Jan 2021 British Journal of Cancer
Phosphorylation-dependent regulation of SPOP by LIMK2 promotes castration-resistant prostate cancer
- Kumar Nikhil
- Hanan S. Haymour
- Kavita Shah
ArticleOpen Access14 Dec 2020 British Journal of Cancer
miR-199b-5p-DDR1-ERK signalling axis suppresses prostate cancer metastasis via inhibiting epithelial-mesenchymal transition
- Zhigang Zhao
- Shankun Zhao
- Jintai Luo
Article26 Nov 2020 British Journal of Cancer
HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours
- Jeffrey C. Francis
- Jennifer R. Gardiner
- Amanda Swain
ArticleOpen Access20 Nov 2020 British Journal of Cancer
Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity
- Adan Pinto-Fernandez
- Mariolina Salio
- Benedikt M. Kessler
ArticleOpen Access20 Nov 2020 British Journal of Cancer
Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
- Lehe Yang
- Feng Zhou
- Chengguang Zhao
ArticleOpen Access30 Oct 2020 British Journal of Cancer
APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer
- Pu-Hyeon Cha
- Jeong-Ha Hwang
- Kang-Yell Choi
ArticleOpen Access19 Oct 2020 British Journal of Cancer
Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer
- Matteo Morotti
- Christos E. Zois
- Adrian L. Harris
ArticleOpen Access8 Oct 2020 British Journal of Cancer
Lysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth
- Jing-Yi Chen
- Chien-Feng Li
- Wen-Chun Hung
ArticleOpen Access7 Oct 2020 British Journal of Cancer
BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair
- Li-Po Wang
- Tzu-Yu Chen
- Show-Li Chen
ArticleOpen Access23 Sep 2020 British Journal of Cancer
Genkwadaphnin inhibits growth and invasion in hepatocellular carcinoma by blocking DHCR24-mediated cholesterol biosynthesis and lipid rafts formation
- Jie Wu
- Ling Guo
- Shaojiang Song
ArticleOpen Access22 Sep 2020 British Journal of Cancer
Evidence for hypoxia increasing the tempo of evolution in glioblastoma
- David Robert Grimes
- Marnix Jansen
- David Basanta
ArticleOpen Access27 Aug 2020 British Journal of Cancer
Differential association of CD68⁺ and CD163⁺ macrophages with macrophage enzymes, whole tumour gene expression and overall survival in advanced melanoma
- Liam Friel Tremble
- Mark McCabe
- Cynthia C. B. B. Heffron
ArticleOpen Access26 Aug 2020 British Journal of Cancer
E2F7−EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression
- Rui Yang
- Mei Wang
- Hongjuan Cui
ArticleOpen Access20 Aug 2020 British Journal of Cancer
Suppression of G6PD induces the expression and bisecting GlcNAc-branched N-glycosylation of E-Cadherin to block epithelial-mesenchymal transition and lymphatic metastasis
- Yifei Wang
- Qingxiang Li
- Chuanbin Guo
ArticleOpen Access28 Jul 2020 British Journal of Cancer
Progesterone receptor membrane component 1 promotes the growth of breast cancers by altering the phosphoproteome and augmenting EGFR/PI3K/AKT signalling
- Diego A. Pedroza
- Venkatesh Rajamanickam
- Rajkumar Lakshmanaswamy
ArticleOpen Access24 Jul 2020 British Journal of Cancer
Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer
- Vito Carlo Alberto Caponio
- Giuseppe Troiano
- Lorenzo Lo Muzio
ArticleOpen Access20 Jul 2020 British Journal of Cancer
A novel TRPM7/O-GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma
- Sudjit Luanpitpong
- Napachai Rodboon
- Surapol Issaragrisil
ArticleOpen Access20 Jul 2020 British Journal of Cancer
Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia
- Stephanie G. Craig
- Matthew P. Humphries
- Manuel Salto-Tellez
ArticleOpen Access20 Jul 2020 British Journal of Cancer
Cancer-associated fibroblasts mediate cancer progression and remodel the tumouroid stroma
- Judith Pape
- Tarig Magdeldin
- Umber Cheema
ArticleOpen Access9 Jul 2020 British Journal of Cancer
Systematic analysis reveals a functional role for STAMBPL1 in the epithelial–mesenchymal transition process across multiple carcinomas
- Gorbatchev Ambroise
- Ting-ting Yu
- Helin Vakifahmetoglu-Norberg
ArticleOpen Access8 Jul 2020 British Journal of Cancer
IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma
- Chun-fen Mo
- Jun Li
- Qiang Zou
Article7 Jul 2020 British Journal of Cancer
Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling
- Gantumur Dolgormaa
- Norifumi Harimoto
- Ken Shirabe
ArticleOpen Access6 Jul 2020 British Journal of Cancer
CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer
- Jian-xian Lin
- Changhwan Yoon
- Chang-ming Huang
ArticleOpen Access1 Jul 2020 British Journal of Cancer
WD repeat-containing protein 1 maintains β-Catenin activity to promote pancreatic cancer aggressiveness
- Hengchao Li
- Xiaohui Liu
- Deliang Fu
ArticleOpen Access30 Jun 2020 British Journal of Cancer
Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer
- Ling Li
- Lisa Hobson
- Michael Ladomery
ArticleOpen Access25 Jun 2020 British Journal of Cancer
Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancer
- Sin-Aye Park
- Nam Ji Sung
- Young-Joon Surh
ArticleOpen Access23 Jun 2020 British Journal of Cancer
YES1 amplification confers trastuzumab–emtansine (T-DM1) resistance in HER2-positive cancer
- Lei Wang
- Quanren Wang
- Liguang Lou
ArticleOpen Access23 Jun 2020 British Journal of Cancer
CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma
- Xue-Tang Mo
- Thomas Ho-Yin Leung
- Hextan Yuen-Sheung Ngan
ArticleOpen Access8 Jun 2020 British Journal of Cancer
ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation
- Sk. Kayum Alam
- Li Wang
- Luke H. Hoeppner
ArticleOpen Access5 Jun 2020 British Journal of Cancer
Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds
- Giovanna Li Petri
- Btissame El Hassouni
- Elisa Giovannetti
ArticleOpen Access4 Jun 2020 British Journal of Cancer
Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription
- Guoqing Wan
- Jiang Zhu
- Changlian Lu
ArticleOpen Access3 Jun 2020 British Journal of Cancer
The role of sex in the innate and adaptive immune environment of metastatic colorectal cancer
- Anita L. Ray
- Robert A. Nofchissey
- Katherine T. Morris
ArticleOpen Access26 May 2020 British Journal of Cancer
CD133 inhibition via autophagic degradation in pemetrexed-resistant lung cancer cells by GMI, a fungal immunomodulatory protein from Ganoderma microsporum
- I-Lun Hsin
- Ling-Yen Chiu
- Jiunn-Liang Ko
ArticleOpen Access25 May 2020 British Journal of Cancer
Omental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2–VEGFA axis
- Makoto Natsume
- Takaya Shimura
- Hiromi Kataoka
ArticleOpen Access22 May 2020 British Journal of Cancer
Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas
- Malgorzata Sielska
- Piotr Przanowski
- Bozena Kaminska
ArticleOpen Access11 May 2020 British Journal of Cancer
Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling in ovarian cancer
- Yu-Xin Jiang
- Michelle Kwan-Yee Siu
- Karen Kar-Loen Chan
ArticleOpen Access11 May 2020 British Journal of Cancer
Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC
- Chao Rong
- Marie F. Muller
- Annette Affolter
ArticleOpen Access19 May 2020 British Journal of Cancer
KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression
- Maria Saveria Gilardini Montani
- Luca Falcinelli
- Mara Cirone
ArticleOpen Access18 May 2020 British Journal of Cancer
Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling
- Xuan Chen
- Shichao Zhuo
- Yufeng Cheng
ArticleOpen Access5 May 2020 British Journal of Cancer
Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion
- Nick Hornigold
- Karen R. Dunn
- Naveen S. Vasudev
ArticleOpen Access11 May 2020 British Journal of Cancer
LncRNA-HNF1A-AS1 functions as a competing endogenous RNA to activate PI3K/AKT signalling pathway by sponging miR-30b-3p in gastric cancer
- Hai-Ting Liu
- Ran-Ran Ma
- Peng Gao
ArticleOpen Access27 Apr 2020 British Journal of Cancer
Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway
- Yunhe Gao
- Jiyang Li
- Lin Chen
ArticleOpen Access30 Apr 2020 British Journal of Cancer
Diagnostic value of ¹⁸F-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8⁺tumour-infiltrating lymphocytes in oral squamous cell carcinoma
- Maria Togo
- Takehiko Yokobori
- Tetsunari Oyama
ArticleOpen Access2 Apr 2020 British Journal of Cancer
Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells
- Xin Wang
- Danxiu Li
- Yuanyuan Lu
ArticleOpen Access25 Mar 2020 British Journal of Cancer
A direct comparison of selective BH3-mimetics reveals BCL-X_L, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma
- Annika Bierbrauer
- Maureen Jacob
- Simone Fulda
ArticleOpen Access18 Mar 2020 British Journal of Cancer

Brief Communications

Platelets enhance malignant behaviours of gastric cancer cells via direct contacts
- Ryo Saito
- Katsutoshi Shoda
- Daisuke Ichikawa
Brief CommunicationOpen Access28 Oct 2020 British Journal of Cancer
Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer
- Lisanne Mout
- Jan M. Moll
- Wytske M. van Weerden
Brief CommunicationOpen Access29 Sep 2020 British Journal of Cancer

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