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Gastric cancer is among the leading cause of cancer-related mortality worldwide. Despite the fact that early diagnosis has improved quality of life and patient outcomes, better understanding of the biology of the disease is needed to design better therapies. Currently, advances in treatment of gastric cancer have been limited mainly due to this neoplasia’s genetic heterogeneity. Consequently, several efforts have been made to further improve our knowledge of gastric cancer biology. In this CGT collection, we include articles focusing on cell signalling, epigenetic mechanisms and immune responses implicated in gastric cancer thus shedding light on novel potential therapeutic strategies.