Single-cell Analysis

April 2011, Volume 8 No 4s ppS1-S40

In a series of commissioned pieces, authors discuss methods for the analysis of single cells and consider technical developments still needed. Three Reviews describe methods to study single-cell gene expression, peptide, and small-molecule metabolite profiles. Two Perspectives describe live-cell imaging and clonal analysis applied to single stem cells. A Commentary provides an overview of the technological developments underlying single-cell analysis and discusses applications of genome analysis in single cells.