Protein misfolding
- Submission status
- Closed
- Submission deadline
A protein’s function depends on a precise quaternary structure. However, when that structure is disrupted through misfolding, not only does the protein lose its function, but it runs the risk of aggregating. Protein aggregation cascades are integral in the pathophysiology of proteinopathies such as prion disease and Alzheimer's disease, where they ultimately lead to atrophy and death. This Collection invites submissions which advance our understanding of the mechanisms of protein misfolding and clearance, and interventions directed at reducing protein aggregates.
Editors
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Arianna Bellucci
University of Brescia, Italy
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YoungSoo Kim
Yonsei University, South Korea
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Kwang Hun Lim
East Carolina University, USA
Arianna Bellucci is an Associate Professor of Pharmacology at University of Brescia, Italy. Her research focuses on the study of alpha-synuclein misfolding and aggregation in neurodegenerative disorders. In particular, she is strongly interested in disclosing how the formation of pathological alpha-synuclein aggregates impacts on synaptic homeostasis and in identifying novel therapeutic targets for Parkinson’s disease and Multiple system Atrophy. Prof Bellucci has been an Editorial Board Member for Scientific Reports since 2019.
YoungSoo Kim is a Professor of Pharmacy at Yonsei University, South Korea. He is a chemical biologist focused on misfolding protein engineering, amyloid-disaggregating drug discovery, plasma test development, and novel drug target investigation. Prof Kim has been an Editorial Board Member for Scientific Reports since 2015.
Kwang Hun Lim is a Professor of Chemistry at East Carolina University, USA. He has been interested in problems in protein misfolding and amyloid formation since his postdoctoral work at University of California at Berkeley. His current research focuses on structural investigation of cytotoxic oligomers and fibrillar aggregates associated with neurodegenerative diseases to unravel structural basis underlying toxicity and spreading of misfolded protein aggregates. Prof Lim has been an Editorial Board Member for Scientific Reports since 2019.
