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The last few years has seen growing interest in the function of epigenetics in cancer initiation and progression. A growing volume of work now underpins our understanding of the role of these non-genetic modifications in the molecular biology of disease initiation and metastatic spread, and how modulating the cell’s epigenetics may be used as a therapeutic strategy. This collection of articles picked by the Editors from Leukemia, Oncogene, the British Journal of Cancer and Blood Cancer Journal, provides you with a snapshot of current epigenetic research in both haematological and solid cancers.