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TRP ion channels in the pathobiology of disease

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The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch”. In recognition of their work, the LI editors present an updated collection of papers that explore the mechanisms of transient receptor potential ion channels.

Transient receptor potential (TRP) ion channels serve as cellular sensors that respond to a range of physical and chemical stimuli.  Twenty-eight mammalian TRP ion channels have been reported, which belong to six subfamilies (TRPV, TRPM, TRPC, TRPA, TRPP, and TRPML).  This collection of articles from Laboratory Investigation describes the roles of various TRP ion channels in inflammation, fibrosis and cancer.

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Fluorescent microscopy image of TRP ion channels

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