Cancer Cell Therapy

Cancer cell therapy has become one of the most promising approaches for cancer treatment. In recent years, progress in the underlying science, clinical application and manufacturing of cell therapies has accelerated dramatically. Multiple approaches are now exploring different immune cell types as therapeutic platforms, as well as genetic approaches to enhance the antitumour potential of these cells. In this collection, three articles discuss some of these approaches and the challenges and opportunities for their clinical implementation.

In the first article, Kuball and colleagues analyse the tumour-specificity mechanisms of γδT cells and the potential to develop these cells into therapies against a broad range of cancers. In the second article, Depil and colleagues discuss the advantages and challenges of developing allogeneic ‘off-the-shelf’ T cell therapies, which could be prepared and optimized in advance. And finally, in the last article, Campana and colleagues discuss therapies based on natural killer (NK) cells, which can recognize and kill tumour cells rapidly and are also good candidates for off-the-shelf cell therapies.