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The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome

Cellular & Molecular Immunology volume 8, pages 486–495 (2011)Cite this article

Abstract

MicroRNAs (miRNAs) are a novel class of small, non-coding RNAs that play a significant role in both inflammatory and cardiovascular diseases. Immune cells, especially T helper (Th) cells, are critical in the development of atherosclerosis and the onset of acute coronary syndrome (ACS). To assess whether inflammation-related miRNAs (such as miR-155, 146a, 21, 125a-5p, 125b, 31) are involved in the imbalance of Th cell subsets in patients with ACS, we measured the expression of related miRNAs in patients with acute myocardial infarction (AMI), unstable angina (UA), stable angina (SA) and chest pain syndrome (CPS); analyzed the relationship between miRNA expression and the frequency of Th cell subsets; and observed the co-expression of miR-155 and IL-17A in peripheral blood mononuclear cells (PBMCs) of patients with ACS. The results showed that the expression of miR-155 in the PBMCs of patients with ACS was decreased by approximately 60%, while the expression of both miR-21 and miR-146a was increased by approximately twofold. The expression patterns of miRNAs in plasma correlated with those in PBMCs, except for miR-21, which was increased by approximately sixfold in the AMI group and showed no significant difference between the UA group and the CPS group. We also found that the expression of miR-155 inversely correlated with the frequency of Th17 cells (r=−0.896, P<0.01) and that miR-155 was co-expressed with IL-17A in patients with ACS. In conclusion, our study revealed the expression patterns of inflammation-related miRNAs in patients with ACS and found that miR-155 may be associated with Th17 cell differentiation.

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Acknowledgements

The work described in this article was supported by the National Natural Science Foundation of China (no. 81000085) and the Doctor and Novo-teacher Foundation of Chinese National Ministry of Education (no. 20090142120049).

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Author notes

  1. Rui Yao and Yulan Ma: Both authors contributed to the work equally.

  2. Dr YH Liao, Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China. E-mail: liaoyh27@163.com

Authors and Affiliations

  1. Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China

    Rui Yao, Yulan Ma, Mengyang Liao, Huanhuan Li, Wei Liang, Jing Yuan, Xian Yu & Yuhua Liao

  2. Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Youyou Du

  3. Department of General Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, China

    ZhijunMa

  4. Pharmaceutical Preparation Section, the First Hospital of Wuhan City, Wuhan, China

    Hong Xiao

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Yao, R., Ma, Y., Du, Y. et al. The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome. Cell Mol Immunol 8, 486–495 (2011). https://doi.org/10.1038/cmi.2011.22

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