Collections

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    CDDpress, with its three journals (Cell Death & Differentiation, Cell Death & Disease, Cell Death Discovery), has just finished the publication for the year 2018, publishing insightful and high-impact articles on the frontlines of cell biology and biochemistry research. In 2018, the journals received nearly 5000 submissions and published around 1400 selected papers. Of particular interest were several pivotal and influential papers highlighting the role of p53 in cancer and other diseases. Here, with the "Best of CDDpress 2018 on p53" collection, we offer a selection of 2017-2018’s most impactful papers on p53. We hope that you will enjoy reading this special collection.

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    In celebration of 25 years of sister journal Cell Death and Differentiation, the Editors of Cell Death and Disease have selected their picks for the top 25 articles published in their journal.

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    The recent 26th ECDO conference ‘From small molecules to translational medicine’ in Saint-Petersburg (locally organized by Professors Zhivotovsky, Barlev and Lavrik) highlighted the recent developments in the field of cell death with a focus on the small molecules discovery and development. Pharmacological targeting via small molecule-based chemical probes has recently emerged as a valuable tool to delineate molecular mechanisms of various cell death pathways and pave the way towards novel therapeutic approaches in cancer, neurodegenerative and autoimmune diseases. We suggest the selection of articles from the CDD press that will lead through a breathtaking journey from the target –oriented drug development to translational applications.

    Image: National Institutes of Health/Stocktrek Images
  • Collection |

    Mitochondria and endoplasmic reticulum (ER) play an essential role in cell physiology through the control of multiple signal transduction pathways. ER and mitochondria continuously exchange messages by a physical association between the two organelles called MAMs (Mitochondria-Associated Membranes). This communication plays a vital role in the cell fate because it has a dramatic consequence for the functioning of all the other intracellular compartments. In recent years, increasing evidence supports the notion that MAMs act as hotspot signaling domains and are deregulated in several human diseases. In this special issue, the involvement of MAMs in important human pathologies is presented.

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    Recent achievements in development of cell death-based approaches to treatment of various diseases are summarized in this collection of articles from Cell Death & Disease. Disturbances in cell death pathways at the molecular level are linked to the pathogenesis of various diseases. Evidence suggests that suppression or activation of one type of cell death can influence the activity of another, which in turn can affect the response of cells to therapy. We hope that this collection attracts attention to this growing area of research, and encourages the further exploitation of cell death mechanisms in the development of new treatments for human disease.

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    Autophagy is used by cells to deliver cytoplasmic material to lysosomes for degradation, and has been implicated in a wide variety of disorders, including cancer, neurodegeneration, infection and inflammatory diseases.

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    Cell Death & Disease is delighted to announce it has published its 1000th article: ''The traditional Chinese medical compound Rocaglamide protects non-malignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.'' To mark this achievement, we have published the following web focus from Cell Death & Disease and Cell Death & Differentiation on anti-cancer therapies. We hope you enjoy this focus including work from the world's most recognized experts in the field of anti-cancer therapies.

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    A web focus from Cell Death & Differentiation, Cell Death & Disease, Nature Reviews Cancer, Nature Cell Biology, Nature Reviews Molecular Cell Biology and Nature Structural & Molecular Biology. We hope you enjoy this focus including work from the world's most recognized experts in the field of autophagy.

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    A web focus from Cell Death & Differentiation and Cell Death & Disease. We hope you enjoy this focus including work from the world's most recognized experts in the field of Parkinson’s disease.

  • Focus |

    The Editors of Cell Death & DifferentiationandCell Death & Diseaseare delighted to share with you a selection of key papers that highlight some of the best work published in the journals over recent years and which also showcase the breadth of scope and coverage that these journals consistently deliver to their readers. We hope you enjoy reading these papers as much as we have!

  • Focus |

    The Editors of Cell Death & DifferentiationandCell Death & Diseaseare delighted to share with you a selection of key papers that highlight some of the best work published in the journals over recent years and which also showcase the breadth of scope and coverage that these journals consistently deliver to their readers. We hope you enjoy reading these papers as much as we have!