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This Collection features our best recent content from CDDpress. Updated each month, this curated list of articles includes content from all three CDDpress titles: Cell Death and Differentiation, Cell Death & Disease, and Cell Death Discovery. Publishing forefront, innovative and international research covering the cell biology, molecular biology, and biochemistry of cell death and disease, we hope you enjoy reading these articles.
Uncontrolled inflammation can lead to chronic diseases since cells of the immune system, but also epithelial and endothelial cells, become inadequately activated producing cytokines, chemokines and lipid mediators. The immunopathology of chronic inflammatory diseases involves cell death, particularly in cells of epithelial origin, resulting in tissue damage and organ dysfunction. In recent years, many targeted therapies have been developed that have led to significant progress in the treatment of allergic and autoimmune diseases.
In this special issue, novel aspects of the pathophysiology of inflammation, including the regulation of pyroptosis and necroptosis, barrier function, and innate immunity, are presented.
In this collection we have showcased the articles from 2018 and 2019 that you have been reading, sharing and citing. This focus features translational studies and review articles from a range of disease areas, highlighting the broad scope of articles that Cell Death & Disease publishes each year.
The 2019 Nobel Prize in Physiology or Medicine was jointly awarded to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability”. Collectively, their research led to an understanding of the elegant mechanism cells use to respond to changes in oxygen levels, a fundamental process that underpins normal physiologic functioning and plays a critical role in several diseases, including cancer. Via a combination of oxygen-dependant targeted destruction of the Hypoxia Inducible Factor and modulation of gene expression, cells are equipped to survive in a fluctuating environment. This pioneering research helped pave the way towards a plethora of medications that target this pathway. In celebration of their success, we have featured some of their articles in this collection, which includes content from Oncogene, British Journal of Cancer, Pediatric Research, Gene Therapy, Cell Death and Disease, and the Journal of Human Hypertension.
CDDpress, with its three journals (Cell Death & Differentiation, Cell Death & Disease, Cell Death Discovery), has just finished the publication for the year 2018, publishing insightful and high-impact articles on the frontlines of cell biology and biochemistry research. In 2018, the journals received nearly 5000 submissions and published around 1400 selected papers. Of particular interest were several pivotal and influential papers highlighting the role of p53 in cancer and other diseases.
Here, with the "Best of CDDpress 2018 on p53" collection, we offer a selection of 2017-2018’s most impactful papers on p53. We hope that you will enjoy reading this special collection.
The recent 26th ECDO conference ‘From small molecules to translational medicine’ in Saint-Petersburg (locally organized by Professors Zhivotovsky, Barlev and Lavrik) highlighted the recent developments in the field of cell death with a focus on the small molecules discovery and development. Pharmacological targeting via small molecule-based chemical probes has recently emerged as a valuable tool to delineate molecular mechanisms of various cell death pathways and pave the way towards novel therapeutic approaches in cancer, neurodegenerative and autoimmune diseases. We suggest the selection of articles from the CDD press that will lead through a breathtaking journey from the target –oriented drug development to translational applications.
Image: National Institutes of Health/Stocktrek Images
Mitochondria and endoplasmic reticulum (ER) play an essential role in cell physiology through the control of multiple signal transduction pathways.
ER and mitochondria continuously exchange messages by a physical association between the two organelles called MAMs (Mitochondria-Associated Membranes). This communication plays a vital role in the cell fate because it has a dramatic consequence for the functioning of all the other intracellular compartments.
In recent years, increasing evidence supports the notion that MAMs act as hotspot signaling domains and are deregulated in several human diseases.
In this special issue, the involvement of MAMs in important human pathologies is presented.
Recent achievements in development of cell death-based approaches to treatment of various diseases are summarized in this collection of articles from Cell Death & Disease. Disturbances in cell death pathways at the molecular level are linked to the pathogenesis of various diseases. Evidence suggests that suppression or activation of one type of cell death can influence the activity of another, which in turn can affect the response of cells to therapy. We hope that this collection attracts attention to this growing area of research, and encourages the further exploitation of cell death mechanisms in the development of new treatments for human disease.
Autophagy is used by cells to deliver cytoplasmic material to lysosomes for degradation, and has been implicated in a wide variety of disorders, including cancer, neurodegeneration, infection and inflammatory diseases.