Translational Therapeutics

Microbubble and ultrasound radioenhancement of bladder cancer

• W T Tran
• S Iradji
• G J Czarnota

Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin

• S G M Piccirillo
• S Dietz
• C Watts

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

• I M Pires
• M M Olcina
• E M Hammond

Normal tissues toxicities triggered by combined anti-angiogenic and radiation therapies: hurdles might be ahead

• M Mangoni
• M-C Vozenin
• E Deutsch

A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice

• M Wehenkel
• J-O Ban
• K B Kim

Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas

• M T Rahman
• K Nakayama
• K Miyazaki

Phase II study of NGR-hTNF in combination with doxorubicin in relapsed ovarian cancer patients

• D Lorusso
• G Scambia
• C Bordignon

CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling

• A Dubrovska
• A Hartung
• P G Schultz

Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo

• B Gibert
• B Eckel
• C Diaz-Latoud

Phase II multi-institutional prospective randomised trial comparing S-1+paclitaxel with S-1+cisplatin in patients with unresectable and/or recurrent advanced gastric cancer

• E Mochiki
• K Ogata
• H Kuwano

False-negative MRI biomarkers of tumour response to targeted cancer therapeutics

• J K R Boult
• Y Jamin
• S P Robinson

γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer

• H Mizugaki
• J Sakakibara-Konishi
• M Nishimura

In vitro analysis of ovarian cancer response to cisplatin, carboplatin, and paclitaxel identifies common pathways that are also associated with overall patient survival

• E Bicaku
• Y Xiong
• J M Lancaster

Clusterin inhibition using OGX-011 synergistically enhances antitumour activity of sorafenib in a human renal cell carcinoma model

• Y Kususda
• H Miyake
• M Fujisawa

Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells

• T Troiani
• L Vecchione
• F Ciardiello

Defining the molecular response to trastuzumab, pertuzumab and combination therapy in ovarian cancer

• A H Sims
• A JM Zweemer
• S P Langdon

Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial

• J Cummings
• M Zweifel
• C Dive

Contrasting effects of diclofenac and ibuprofen on active imatinib uptake into leukaemic cells

• J Wang
• T P Hughes
• D L White

The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction

• G Descamps
• P Gomez-Bougie
• M Amiot

The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function

• L C J Baker
• J K R Boult
• S P Robinson