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Metastasis
The incurability of metastatic cancer is currently an unmet clinical need which needs to be addressed. This Collection on Metastasis highlights the ongoing challenges in the field and research being undertaken to more thoroughly understand models of metastasis, disrupt the metastatic cascade, and improve treatment outcomes for patients. Featuring Special Issue content that has been curated by Suzanne Fuqua (Baylor College of Medicine, USA), this Collection contains a selection of articles and commissioned content from leading researchers, to present a broad-scope view of current research focal points and explore future directions of cancer metastasis.
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Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion
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Risk-reducing mastectomy and breast cancer mortality in women with a BRCA1 or BRCA2 pathogenic variant: an international analysis
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Long-term outcomes of neoadjuvant immunotherapy plus chemotherapy in patients with early-stage triple-negative breast cancer: an extracted individual patient data and trial-level meta-analysis
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Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer