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    Knopp Biosciences’ investigational, first-in-class drug, dexpramipexole, holds promise for patients with asthma and eosinophil-associated diseases.

    • Knopp Biosciences
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    RevoluGen has designed Fire Monkey, a fast, easy-to-use spin column that extracts optimal DNA for long-read sequencing and is already being used in a number of applications.

    • Revolugen Ltd
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    Genome & Company is developing a microbiome-based add-on therapy for programmed cell death 1/programmed cell death 1 ligand 1 inhibitors. It is also developing novel targeted immune checkpoint inhibitors and believes these two approaches could be combined for personalized therapy.

    • Genome & Company
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    Actimed Therapeutics is developing anabolic/catabolic transforming agents: a new class of agents to treat cachexia, an often fatal condition associated with many chronic diseases including cancer.

    • Actimed Therapeutics
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    Axial Therapeutics focuses on the gut–brain axis to develop therapeutics to mitigate central nervous system disorders and conditions. The company has built a pipeline of novel small molecules with lead programs in autism spectrum disorder and Parkinson’s disease.

    • Axial Biotherapeutics
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    Maximizing the potential of the resident gut microbiome, Kaleido Biosciences is developing novel glycans with the ability to change the metabolic output of the microbiome and have a clinically significant impact across a broad range of diseases.

    • Kaleido Biosciences
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    Symberix is integrating gut microbiome-targeted ‘symbiotic drugs’ and precision medicine strategies into small-molecule drug discovery, and is seeking corporate partners who are ready to transform pharmaceutical R&D and life cycle management.

    • Symberix, Inc.
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    Hofseth BioCare is transforming marine raw materials into products to improve worldwide health conditions including treatments for gastrointestinal diseases, respiratory disorders and cardiovascular health.

    • Hofseth Biocare ASA
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    Novome’s novel platform develops genetically engineered microbial medicines (GEMMs) for chronic disease, offering the potential to act as a delivery system for novel therapeutic functionality, including proteins and peptides, into the gut microenvironment.

    • Novome Biotechnologies
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    Biosortia is building the world’s largest library of microbiome-derived compounds for therapeutic and other applications, by leveraging the company’s microbial harvesting platform to sample and mine aquatic microbiomes at unprecedented scales with sustainable and environmentally friendly approaches. Biosortia is seeking partners interested in accessing compounds and chemistries to develop biologically relevant small molecule leads.

    • Biosortia Pharmaceuticals
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    Kancera, the Swedish company developing drugs to block hyperinflammation and protect function of vital organs, has commenced a phase 2 clinical trial of KAND567, a drug candidate which antagonizes the fractalkine receptor believed to trigger life-threatening inflammatory processes in COVID-19 and heart attack patients.

    • Kancera AB
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    Swiss-based DiNAQOR has developed a revolutionary gene therapy platform which combines gene-vector-promoter constructs with loco-regional delivery to the heart for the treatment of cardiovascular diseases. With its first AAV gene therapy program, DiNA-001, in development for the treatment of MYBPC3 hypertrophic cardiomyopathy (HCM), the company and its platform is attracting significant partnering interest.

    • DiNAQOR AG
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    By combining machine learning with multiple proteins and proprietary algorithms, Prevencio has developed a portfolio of HART tests that accurately diagnose cardiovascular diseases. Prevencio also offers custom diagnostic services.

    • Prevencio
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    NovaGo Therapeutics is developing a first-in-class fully human antibody therapy to treat diabetic retinopathy. With its novel disease-modifying mode of action, it could save the sight of the many patients who respond poorly to current treatments.

    • NovaGo Therapeutics AG
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    Viome has developed the world’s largest metatranscriptomic platform for analyzing human and microbial functions at the molecular level to discover novel mechanisms underlying chronic diseases, cancer, and aging. The company is seeking partners to develop diagnostics, companion diagnostics, and therapeutics based on targets identified using the Viome platform.

    • Viome, Inc.
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    By reprogramming the tumor microenvironment Kineta is developing an anti-VISTA immuno-oncology therapy for the treatment of a variety of cancers, including gastric, ovarian, lung and pancreatic cancers.

    • Kineta, Inc.
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    Using its MicroRx platform, 4D pharma is pioneering the development of an emerging class of therapeutics known as live biotherapeutic products to treat a range of indications from cancer and respiratory disease to neurodegeneration.

    • 4D Pharma PLC
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    Sorrento Therapeutics, Inc. is developing a pipeline of fully human immunotherapies selected from its proprietary G-MAB library. Backed by a platform covering discovery, advanced clinical development, manufacturing and a proven track record of commercialization, it seeks to deliver life-changing therapies.

    • Sorrento Therapeutics
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    Privately held Creatv MicroTech has developed LifeTracDx tests to detect cancer at the earliest stages, and for providing diagnoses to guide cancer treatments, thereby saving and improving lives.

    • Creatv MicroTech
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    RubrYc Therapeutics has established an antibody discovery engine for the development of epitope-targeted biotherapeutics. Through machine learning, the platform helps reveal natural subdominant and alternative epitopes to target for optimized bio-superior design and as access points to traditionally ‘undruggable’ proteins.

    • RubrYc Therapeutics
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    Biotech company APO-T is developing bispecific T cell engagers (BiTEs) that facilitate the attraction of immune effector cells exclusively to cancer sites by targeting cancer cell antigens known as melanoma-associated antigen A (MAGE-A) proteins.

    • APO-T
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    IGY Life Sciences has optimized the sustainable generation of highly specific and efficacious egg-derived IgY antibodies for human and animal health. The company’s pipeline includes marketed immune and sports health products, and lead compounds against COVID-19 and African swine fever.

    • IGY Life Sciences
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    Combining the precision of antibody targeting with α-amanitin, a novel payload, Heidelberg Pharma has developed a powerful therapeutic platform, with the potential to treat a broad range of cancers.

    • Heidelberg Pharma
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    3T Biosciences has developed an immune response-guided approach for identifying pharmacologically active T cell receptors and their targets in solid tumors. With a pipeline of therapeutics targeting novel tumor antigens, 3T is seeking partners to advance these programs.

    • 3T Biosciences
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    ExosomeDx harnesses biological information from exosomes for biomarker discovery and diagnostic development. The company’s pipeline of products includes the ExoDx Prostate test, the first exosome-based liquid biopsy on the market, and various discovery platforms to help solve biopharma’s biomarker-related needs.

    • Exosome Diagnostics
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    Rakuten Medical, a clinical-stage privately funded biotechnology company, is developing first-in-class targeted cancer therapies based on Illuminox, a new platform with the potential to treat many types of solid tumor, one of the leading causes of death globally.

    • Rakuten Medical
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    Employing its deep understanding of G-protein coupled receptors (GPCRs) the Beacon Discovery team has delivered more than 20 compounds into clinical development over the past two decades, and is now working with partners to unlock the therapeutic value of challenging receptors in this class.

    • Beacon Discovery
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    GEMoaB’s three proprietary technology platforms have produced a deep pipeline of immunotherapy assets, three of which are currently being investigated in clinical studies, providing the basis for future growth.

    • GEMoaB Monoclonals GmbH