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The first steps towards the era of personalised vaccinology: predicting adverse reactions

The Pharmacogenomics Journal volume 15, pages 284–287 (2015)Cite this article

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Abstract

Until now, the occurrence of adverse reactions among individuals inoculated with identical vaccines has been ascribed to unpredictable stochastic processes. Recent advances in pharmacogenomics indicate that some features of host response to immunisation are influenced by genetic traits, henceforth predictable. The ability to predict the adverse reaction to vaccination would represent an important step towards the development of personalised vaccinology and could enhance public confidence in the safety of vaccines. Herein, we have reviewed all the available information on the association between genetic variants and the risk for healthy subjects to develop adverse reactions.

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Acknowledgements

This work was supported by grants from the Italian Medicines Agency (Agenzia Italiana del Farmaco) and the Ministry of Health (Ricerca Corrente 2014) to EC.

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Authors and Affiliations

  1. Department of Biomedical and Clinical Sciences, Unit of Clinical Pharmacology, University Hospital ‘Luigi Sacco’, Universitá di Milano, Milan, Italy

    P Pellegrino, F S Falvella, V Perrone, C Carnovale, T Brusadelli, S Cheli, C Perrotta & S Radice

  2. Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy

    M Pozzi & E Clementi

  3. IRCCS Foundation Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    S Antoniazzi

  4. Department of Biomedical and Clinical Sciences, Unit of Clinical Pharmacology, Consiglio Nazionale delle Ricerche Institute of Neuroscience, University Hospital ‘Luigi Sacco’, Universitá di Milano, Milan, Italy,

    E Clementi

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  1. P Pellegrino
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Correspondence to E Clementi.

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Pellegrino, P., Falvella, F., Perrone, V. et al. The first steps towards the era of personalised vaccinology: predicting adverse reactions. Pharmacogenomics J 15, 284–287 (2015). https://doi.org/10.1038/tpj.2014.57

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