Table 2 Summary of GWAS and replication analyses in all asthma clinical trials

From: A genome-wide association study of bronchodilator response in asthmatics

SNP Chr MA MAF Gene Model CAMP GWAS Replication 1 Replication 2 Liptak combined P-value
       (effect estimate) Pooled AT/LOCCS/LODO ACRN CARE GACRS  
rs11252394 10 A 0.08   Additive 0.0099a (+) 1.21E-06 0.4173 0.3472 1.98E-07
rs6988229 8 T 0.20 COL22A1 Recessive 0.0004b (+) 0.0050 0.0505 0.9283 0.0139 8.51E-06
rs9552679 13 C 0.26   Additive 0.0007c (−) 0.0004 0.7884 0.4410 3.02E-05
rs1663330 14 G 0.33   Additive 0.0020a (+) 0.0028 0.0234 0.7544 4.54E-05
rs1663332 14 T 0.37   Additive 0.0028a (+) 0.0006 0.0374 0.6874 0.3595 8.07E-05
rs17495520 5 T 0.14   Additive 0.038a (+) 0.0110 0.0030 0.3587 0.0003
rs10511905 9 G 0.22   Additive 0.006d (−) 0.0087 0.1388 0.3149 0.0003
rs518350 22 T 0.12   Recessive 0.0065e (+) 0.0010 0.4987 0.2090 0.3334 2.70E-04
rs17701271 4 A 0.22   Recessive 0.004b (+) 0.0026 0.1371 0.8756 0.2031 0.0003
rs6002674 22 C 0.15   Recessive 0.0012e (−) 0.0040 0.9808 0.0310 0.5675 0.0027
rs1419555 7 T 0.37   Additive 0.0043c (+) 0.0060 0.7723 0.6879 0.4932 0.0068
rs1423515 5 A 0.05   Additive 0.027a (+) 0.0400 0.4104 0.4710 0.0089
rs1522113 4 A 0.05 CLOCK Additive 0.014a (+) 0.0037 0.9260 0.0427 0.8633 0.0177
  1. Abbreviations: ACRN, Asthma Clinical Research Network; AT, Asthma Trial; CAMP, Childhood Asthma Management Program; Chr, chromosome; CARE, Childhood Asthma Research and Education Network; GACRS, Genetics of Asthma in Costa Rica Study; GWAS, genome-wide association study; LOCCS, Leukotriene modifier or Corticosteroid or Corticosteroid Salmeterol; LODO, Effectiveness of Low Dose Theophylline as Add-on Treatment in Asthma; MA, minor allele; MAF, minor allele frequency in CAMP; SNP, single-nucleotide polymorphisms.
  2. Association results for 13 replicated SNPs (P-values <0.05) from the primary replication phase only are shown, sorted by Liptak Combined P-values. The P-values presented for CAMP are two-sided whereas P-values for the replication populations are one-sided, based on the direction of association (denoted as ‘+’or ‘−’) relative to the CAMP analysis.
  3. aLowest P-value is with the additive generalized linear model.
  4. Lowest P-value is with the recessive generalized linear model.
  5. Lowest P-value is with the additive longitudinal analysis.
  6. Lowest P-value is with the family-based association test (FBAT).
  7. Lowest P-value is with the recessive longitudinal analysis.