Table 2 Differential plasma lipids between control and PD groups at age 11

From: Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort

Lipid name Control (n=67) Cases (n=38) P-value FDR-adjusted
CE(18:2) 13481.42±4506.22 15773.88±3728.61 0.0392 0.242
CE(18:2)+unknown CE (667.6219) 6568.58±2222.39 7967.17±2181.29 0.0313 0.2391
LPC(16:1) 38.27±5.84 41.23±7.13 0.0119 0.1776
LPC(18:1) 231.84±63.24 268.76±77.1 0.0028 0.0972
LPC(18:2) 394.75±128.23 502.39±181.49 <0.0001 0.0179
LPC(20:3) 37.21±6.83 41.1±8.13 0.0003 0.0269
LPC(20:4) 63.03±14.89 66.84±15.93 0.0246 0.2282
PC(16:0e/18:1(9Z)) 92±29.94 105.2±28.8 0.0368 0.2391
PC(30:0) 56.88±16.51 65.36±23.83 0.0165 0.1981
PC(32:0) 175.51±39.91 200.61±38.49 0.0083 0.1486
PC(32:1) 238.88±90.72 288.76±113.49 0.0231 0.2282
PC(32:2) 61.56±20.85 72.75±21.5 0.0027 0.0972
PC(34:2) 3759.47±717.83 4257.93±741.34 0.0065 0.0972
PC(36:2) 2940.24±630.99 3360.9±623.41 0.0125 0.1776
PC(36:3) 1753.26±669.47 2152.76±569.66 0.0349 0.2391
PC(36:4 404.62±165.27 504.24±198.32 0.0038 0.0972
PC(38:2) 70.5±22.97 81.8±22.28 0.0244 0.2282
PC(38:4) 36.07±10.37 40.94±10.62 0.0374 0.2391
PC(40:6) 56.74±20.41 64.26±17.7 0.0357 0.2391
PC(O-32:0) 49.78±11.18 55.84±11.43 0.0078 0.1486
PC(O-32:1) 37.88±7.19 40.82±7.11 0.0353 0.2391
PC(O-34:2) 85.95±27.42 98.13±30.17 0.0255 0.2282
PC(O-34:3) 111.62±33.27 132.51±36.51 0.0036 0.0972
PC(O-36:2) 51.25±15.7 57.48±14.77 0.0166 0.1981
PC(O-36:3) 42.86±11.11 47.38±11.72 0.0277 0.2361
PC(O-38:6) 74.25±23.67 84.11±22.81 0.0455 0.2627
SM(d18:0/16:0) 829.78±212.45 933.75±194.41 0.0129 0.1776
SM(d18:1/24:0) 6167.04±2537.94 7281.12±2418.58 0.0029 0.0972
SM(d41:1) 3540.52±1381.32 3889.15±1148.96 0.0419 0.25
SM(d42:2) 15796±5875.87 18218.69±5133.36 0.0339 0.2391
TG(56:7) 103.59±97.25 76.17±46.64 0.0198 0.2215
  1. Abbreviations: CE, cholesterol ester; LPC, lysophosphatidylcholine; PC, phosphatidylcholine; PD, psychotic disorder; SM, sphingomyelin; TG, triacylglycerol.
  2. Values are expressed as standard units±s.d. (standard deviation). P-values are adjusted for gender and BMI. FDR-adjusted P-values are adjusted for multiple comparisons using the Benjamini–Hochberg procedure. Values in bold are lipids that remain significant (P<0.1) folllowing correction for multiple comparisons.