Figure 1 | Translational Psychiatry

Figure 1

From: Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose

Figure 1

In a biphasic manner, cannabidiol inhibited the binding of [3H]domperidone to dopamine D2 receptors in rat brain homogenized striata, similar to the biphasic pattern for other dopamine agonists and the partial dopamine agonist antipsychotic aripiprazole. The earlier published data for aripiprazole12 are redrawn here to show the similarity to cannabidiol. Olanzapine (redrawn from Seeman et al.13) and all other antipsychotic antagonists do not reveal a biphasic pattern when using any antagonist radioligand for D2.

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