Figure 3

From: Meditation and vacation effects have an impact on disease-associated molecular phenotypes

Figure 3

Identifying network structures in a blood Bayesian network reflecting vacation and meditation effects. (a) The red, brown, pink and purple coexpression network modules enriched for the vacation signature were projected on a blood Bayesian network. The subnetwork depicted is the largest connected subgraph comprising nodes within a path length of one of the projected nodes. The pink nodes represent genes in the vacation signature (2.7-fold enriched; Fisher exact test (FET) P=5.6e−19), green nodes are genes annotated as Alzheimer’s disease genes (2.3-fold enriched; FET=0.012) and orange nodes are genes annotated as telomere genes. (b) Network constructed as in a using genes from the salmon, tan, blue and black modules all enriched for genes in the meditation signature. The blue nodes represent meditation signature genes (2.4-fold enriched; FET P=6.5e−5) and the orange nodes represent genes annotated as telomere genes (1.7-fold enriched; FET P=0.045). Oversized nodes with red borders are discussed in the main text.