Figure 3

From: Region-specific alterations of A-to-I RNA editing of serotonin 2c receptor in the cortex of suicides with major depression

Figure 3

Brain regional specificity of changes in 5-HT2CR mRNA editing in suicide victims and non-psychiatric controls. (a) Comparison of the relative isoform proportion of 5-HT2CR mRNA in BA24 (n=7) and Brodmann area 9 (BA9; n=7) within the control group (see Figure 1a Q1). The 5-HT2CR isoforms are depicted in order of statistical significance and relative proportion in BA24. (b) Comparison of the relative mRNA-isoform proportion of 5-HT2CR in BA24 (n=7) and BA9 (n=8) in the suicide group in the same order as in a (see Figure 1a Q2). Filled yellow bars indicate the most significant differences in relative proportion of the isoform between the two brain structures in both control and suicide groups. (c) Comparison of the relative isoform proportion of 5-HT2CR in control (n=7) and suicide (n=7) groups within BA24 area (see Figure 1a Q3). The 5-HT2CR isoforms are depicted in order of statistical significance and relative proportion in the suicide group. A negative value indicates a relative decrease in isoform presence. Inversely, an increase in the relative proportion is indicated by a positive value. (d) Comparison of the relative isoform proportion of 5-HT2CR in control (n=7) and suicide (n=8) groups within the BA9 area (see Figure 1a Q4). Filled yellow bars indicate most significant differences between control and suicide groups. Criteria for the selection are (1) a P-value 0.05 using the one-sample Wilcoxon signed rank test (where null hypothesis H0: median variation=0) and (2) a median variation less than equal to ±20%. *P0.05, **P0.01 and ***P0.001.