Table 2 Categorical outcomes at week 6

From: A mega-analysis of fixed-dose trials reveals dose-dependency and a rapid onset of action for the antidepressant effect of three selective serotonin reuptake inhibitors

Group Response Remission
  % Odds ratio (CI) P % Odds ratio (CI) P
HDRS-17
 Placebo versus low-dose 44.7 51.6 1.32 (1.01–1.72) 0.04 24.8 33.5 1.53 (1.13–2.06) 0.005
 Placebo versus optimal-dose 44.7 61.6 1.98 (1.53–2.57) <0.001 24.8 39.9 2.01 (1.51–2.68) <0.001
 Low-dose versus optimal-dose 51.6 61.6 1.51 (1.19–1.90) <0.001 33.5 39.9 1.32 (1.03–1.68) 0.03
Depressed mood
 Placebo versus low-dose 70.5 78.8 1.56 (1.15–2.13) 0.005 15.6 27.9 2.09 (1.47–2.96) <0.001
 Placebo versus optimal-dose 70.5 85.9 2.56 (1.86–3.50) <0.001 15.6 35.0 2.91 (2.08–4.06) <0.001
 Low-dose versus optimal-dose 78.8 85.9 1.64 (1.21–2.22) 0.002 27.9 35.0 1.39 (1.08–1.80) 0.01
  1. Abbreviation: CI, confidence interval; HDRS-17, Hamilton Depression Rating Scale 17-item version.