Figure 2 | Translational Psychiatry

Figure 2

From: A mega-analysis of fixed-dose trials reveals dose-dependency and a rapid onset of action for the antidepressant effect of three selective serotonin reuptake inhibitors

Figure 2

Trajectories of change, effect sizes (ES) and levels of significance for the pooled analyses comprising all subjects. Shown are the mean reductions on the 17 item Hamilton Depression Rating Scale (HDRS-17-sum) (panel a) and depressed mood (panel b). ES and levels of significance for all comparisons between treatment groups are displayed in the lower parts of the graph (L, low-dose; O, optimal-dose; P, placebo; v, versus): *P<0.05, **P<0.01, ***P<0.001.

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