Table 2 Amino-acid levels in post-mortem brain tissue samples

From: d-serine levels in Alzheimer’s disease: implications for novel biomarker development

Amino acid (nmolg−1 WT) Control AD ANCOVA F (P-value)
Hippocampus
d-serine 18.1 (5.1) 33.0 (4.0)a 9.00 (0.001)*
l-serine 1371 (234) 1061 (175) 0.56 (0.58)
 Total serine 1388 (243) 1270 (182) 0.11 (0.90)
 Glycine 1191 (255.6) 1017 (249) 1.05 (0.13)
Parietal cortex
d-serine 11.8 (5.44) 36.2 (4.43)a 6.08 (0.013)*
l-serine 2453 (390) 2434 (308) 0.54 (0.60)
 Total serine 2465 (388) 2473 (307) 0.54 (0.60)
 Glycine 3679 (57.2) 4058 (140.1) 6.00 (0.0005)*
Occipital cortex
d-serine 1.73 (0.34) 1.76 (0.29) 0.49 (0.62)
l-serine 75.0 (17.1) 110.5 (14.4) 2.53 (0.10)
 Total serine 76.7 (22.2) 128.4 (18.7) 2.02 (0.16)
 Glycine 194(43.7) 284.5 (202.2) 21.42 (0.23)
  1. Abbreviations: AD, Alzheimer’s disease; ANCOVA, analysis of covariance; WT, wet tissue.
  2. Values are presented as means (s.e.). P-values were given by ANCOVA using age as covariate, followed by the Bonferroni adjustment for multiple comparisons. Asterisks indicate statistically significant differences.
  3. aAD significantly different from control (P<0.05).