Table 3 MANEA rs1133503 genotype is associated with panic disorder and generalized social anxiety disorder diagnosis in different European American samples

From: The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder

Group Genotype count (frequency) Odds ratio (95% CI) a P-value
  TT CT CC   
Sample 1 - panic disorder Cases 49 (25.7%) 107 (56.0%) 35 (18.3%)   
  Controls 694 (36.9%) 867 (46.1%) 321 (17.1%) 1.7 (1.21–2.40)b 0.002
Sample 2 - panic disorder Cases 36 (25.4%) 74 (52.1%) 32 (22.5%)   
  Controls 188 (34.2%) 268 (48.7%) 94 (17.1%) 1.53 (1.01–2.33)c 0.043
Sample 3 - GSAD Cases 28 (21.4%) 87 (66.4%) 16 (12.2%)   
  Controls 74 (36.6%) 96 (47.5%) 32 (15.8%) 2.15 (1.27–3.64)d 0.004
  1. Abbreviation: GSAD, generalized social anxiety disorder.
  2. aRisk associated with carrying the C-allele of rs1133503.
  3. bAdjusted for sex, age and cocaine-induced paranoia.
  4. cAdjusted for sex and age.
  5. dAdjusted for sex.