Figure 4: Effects of intravitreal injections of VCP modulator on retinal ischemic rat model. | Scientific Reports

Figure 4: Effects of intravitreal injections of VCP modulator on retinal ischemic rat model.

From: KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress

Figure 4

(a) Longitudinal changes in inner retinal thickness in the control (n = 13, triangles) and IVT-KUS121–treated (n = 11, circles) groups. Inner retinal thickness was significantly greater in the IVT-KUS121–treated group than in the control group 7 and 14 days after ischemic retinal injury. Error bars indicate SD. ***P < 0.001 vs. control (Student’s t test). (b) RGC number in the control (n = 15) and IVT-KUS121–treated (n = 20) groups, confirming significant preservation of RGC number in the IVT-KUS121–treated group compared with the control group after ischemic retinal injury. Error bars indicate SE. **P < 0.01 vs. control (Student’s t test). (c) a-wave and b-wave amplitudes of electroretinography recordings of rats in the control (n = 21) and IVT-KUS121–treated (n = 24) groups before ischemic injury, 7 days after ischemic injury, and 14 days after ischemic injury. Rats treated with IVT-KUS121 showed a significant preservation of b-wave amplitude 14 days after ischemic injury. Error bars indicate SD. ***P < 0.005 vs. control (Aspin-Welch t test).

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