Figure 8 : Schematic model comparing balanced perilacunar remodeling with glucocorticoid-mediated suppression.

From: Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis

Figure 8

Within the bone matrix during normal perilacunar remodeling (A), there exists extensive lacunocanalicular connectivity, linearized collagen, and maintenance of mineral content around the osteocyte lacuna. Inset shows linearized collagen. In the presence of excess glucocorticoids (B), perilacunar remodeling is suppressed. Dysregulation of osteocyte enzyme expression likely precedes changes in bone matrix collagen alignment, lacunocanalicular circulation, and mineralization status; all of which contribute to the poor bone quality, sclerosis and increased fracture risk observed in osteonecrosis. Inset shows disorganized collagen matrix with accompanying hypermineralization. Illustration by M. Ouchida.