Figure 4 : Hypermineralization develops rapidly and persists during GC treatment in cortical and trabecular bone.

From: Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis

Figure 4

(A,B) Representative color scaled 3D rendered images of SRμT from trabecular bone of 7-day placebo (A) and prednisolone (B) -treated animals display a shift toward more highly mineralized bone with GC treatment. (C,G) Grey-scale 3D rendered images of SRμT highlight trabecular (C) and cortical (G) ROI that were analyzed quantitatively. Mineral density plotted against percent bone volume for day 7 (D,H) and day 21 (E,I) (dotted vertical lines correspond to peak mineral density) show significantly increased mineralization in prednisolone-treated bones, as quantified for trabecular (F) and cortical (J) bone. For all analyses, bars represent mean ± SEM *p-value ≤ 0.05, n ≥ 3.