Figure 2 : In vitro exposure of bladder tissue to inosine decreases spontaneous activity (SA).

From: Inosine attenuates spontaneous activity in the rat neurogenic bladder through an A2B pathway

Figure 2

(A) Summary graph demonstrating a significant difference in baseline spontaneous activity between bladder tissues from control (uninjured) and SCI rats (#p < 0.05), as well as a significant inhibitory effect of exogenous inosine (1 mM) on spontaneous activity in tissue from control (*p < 0.05, baseline vs. inosine) and SCI (**p < 0.01, baseline vs. inosine) rats. (B) Basal tone was also inhibited significantly by inosine in tissue from control and SCI rats (**p < 0.01). (C) Representative trace indicating the dose-dependent effect of exogenous inosine when administered to SCI bladder tissue. (D) Tone was significantly decreased with increasing doses of inosine (***p < 0.001). (E,F) Summary graphs illustrating that inosine (1 mM) decreased the amplitude of both low (**p < 0.01) and high frequency (*p < 0.05, n = 8) components of SA. (G–J) Inosine also decreased the tone and amplitude of SA in SCI bladder strips without mucosa. Amplitude data were normalised by baseline responses. Data are presented as mean ± SEM.