Figure 1 | Scientific Reports

Figure 1

From: Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis

Figure 1

Effect of PcTx1 or mambalgin-1 (Mamb-1) bilateral microinjection (0.05 and 0.065 μg/rat/side, respectively, 15 min before the test) within the BLA of sham and MoAr rats on mechanical (A for PcTx1, C for manbalgin-1) and thermal (B, PcTx1 only) hyperalgesia using paw pressure and paw immersion test at 46 °C. Tests were performed 14–16 days following monoarthritis induction. Arrows indicated the injection of the inhibitor. n = 6–8 animals per group. Two-way repeated measures ANOVA followed by a Tuckey post hoc test. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 compared to sham saline group, °p ≤ 0.05, °°p ≤ 0.01, °°°p ≤ 0.001 compared to MoAr saline group.

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