1-Ethyl-3-methylimidazolium acetate as a highly efficient organocatalyst for cyanosilylation of carbonyl compounds with trimethylsilyl cyanide

1-Ethyl-3-methylimidazolium acetate is introduced as a robust organocatalyst for solvent-free cyanosilylation of carbonyl compounds with trimethylsilyl cyanide (TMSCN). The catalyst loading can be reduced to as low as 0.1–0.0001 mol % under mild reaction conditions, giving considerably high TOF values from 10,843 h−1 to 10,602,410 h−1 in the field of organocatalyzed transformations. The present protocol not only tolerates with extensive carbonyl compounds but also provides somewhat insight into the mechanism of ionic liquids (ILs)-catalyzed reactions.


Results and Discussion
We started our studies by examination of the catalytic activity of a set of imidazolium-based ILs, using the cyanosilylation of benzaldehyde with TMSCN as a model reaction (Table 1). In the presence of 0.01 mol % of catalyst loading, imidazolium-based ILs with various counter anions demonstrated different catalytic activities. Imidazolium-based ILs with counter anions such as OAc − , SCN − and (EtO) 2 PO 2 − were obviously efficient even with lower catalyst loading (0.005 mol %) in promoting this transformation, giving the product in excellent yield within 5 minutes (Table 1, (Table 1, entries 4-9) 49 . Among all the imidazolium-based ILs tested, [EMIM]OAc was the most efficient catalyst, which is in accordance with its basicity and accordingly underlines the possible anion-activation mechanistic mode. Furthermore, we performed several control experiments by switching imidazolium cation to other types of cations i.e., tetrabutylphosphonium, ammonium, sodium as well as potassium etc. (Table 1, entries 10-13), most of them were not efficient for this reaction with an exception of tetrabutylphosphonium cation (78% yield), suggesting that both cations and anions were essential for catalytic efficiencies. It is worth of noting that the catalytic activities of ILs and other salts having acetate anions seemed to agree with the interaction strength between cation and anion pairs 49 . In the absence of catalyst, only trace amount of the desired product was detected (Table 1, entry 14). Among all the screened catalytic protocols, [EMIM]OAc (1a) was found as an efficient catalyst for cyanosilylation of benzaldehyde with TMSCN. In view of the high efficacy and readily availability of 1a, we employed it as the corresponding catalyst for further cyanosilylation optimizations.
In the next, we optimized the reaction conditions in terms of solvents and catalyst loadings, and the results were summarized in Table 2. In the presence of 0.01 mol % of 1a, the reaction performed in toluene, CH 2 Cl 2 , CHCl 3 , and THF proceeds smoothly to give the product with a yield of 94%, 83%, 88%, and 85%, respectively ( Table 2, entries 1-4). The reaction in CH 3 CN was substantially suppressed due to its high polarity, only 48% yield was obtained in 5 minutes (Table 2, entry 5). To our delight, the reaction under neat conditions affords the product in quantitative yield (Table 2, entry 6). Also with reduced amount of catalyst, i.e., 0.005 mol % of 1a, we obtained 94% yield within 5 minutes under solvent-free conditions (Table 2, entry 7). We were pleased to find that the catalyst loading of 1a can further be reduced to 0.001 mol % with 87% yield at a prolonged reaction time ( Table 2, entry 8). Using acetophenone as a substrate, the catalyst loading of 1a needs to increase up to 0.1 mol % for completing the reaction within 5 minutes (Table 2, entry 10). We selected 0.005 mol % and 0.1 mol % catalyst loading of 1a with neat reaction conditions as optimal choices for further applications in cyanosilylation of aldehydes and ketones, respectively. Under the optimized reaction conditions, various aldehydes were subjected to this protocol and the results were summarized in Table 3. The cyanosilylation of benzaldehyde with TMSCN produced 94% yield within 5 minutes in the presence of 0.005 mol % of 1a under neat reaction conditions (Table 3, entry 1). Benzaldehyde derivatives substituted with electron withdrawing groups (EWGs) reacted much faster than those having electron donating groups (EDGs). Even with as low as 0.001 mol % of 1a, benzaldehyde derivatives having electron withdrawing substituents such as p-chloro and m-fluoro afforded excellent yield (Table 3, entries 2-3). In contrast, benzaldehyde derivatives substituted with EDGs such as 3-methoxyl group, a satisfactory yield was obtained when the catalyst loading was increased to 0.1 mol % (Table 3, entry 4). Cinnamaldehyde required prolonged reaction time to get a satisfactory yield, and was essentially converted to 1,2-adducts, meanwhile leaving the olefin functional group unchanged (Table 3, entry 5) 12,50 . In line with the electron poor aromatic aldehydes, 0.001 mol % of 1a was also effective enough for aliphatic aldehydes (   With the optimized reaction conditions in hand, ketones were employed as substrates and the results were summarized in Table 4. In the presence of 0.1 mol % of 1a, both aromatic and aliphatic ketones provided excellent yield ( Table 4, entries 1-8). The substituent on aromatic ketones did not show considerable influence on the reaction outcomes. Under the same reaction conditions, 1a is also capable to convert the relatively unreactive benzophenone into its product with excellent yield (Table 4, entry 9) 32 .
The exact mechanism for 1a catalyzed cyanosilylation is still unclear. Our original mechanistic proposal was based on a synergistic activation mode, i.e., imidazolium cation interacts with carbonyl compounds by facilitating the attack of acetate anion activated TMSCN and it was considered that the reaction may proceed through hypervalent silicate intermediate 10, (Fig. 1) 29,[51][52][53][54] . The formation of hypervalent silicate intermediate between acetate anion and TMSCN was confirmed by 1 H NMR spectra of TMSCN and a 1:1 mixture of TMSCN and 1a in CDCl 3 (for detail of 1 H NMR spectra, see Supplementary page S13). On the other hand, a connection with recently discovered "carbene from imidazolium-based ILs" was also under consideration [55][56][57][58][59][60][61] , in which the in situ generated NHC by deprotonation of carbon-2 at imidazolium cation with its acetate anion may act as an efficient catalyst for cyanosilylation of carbonyl compounds 3,26,[31][32][33][34][35]59 . In order to gain insight into this mechanistic mode, we intentionally blocked the C-2 position of imidazolium cation with a methyl group by preparing 1-ethyl-2,3-dimethylimidazolium acetate [EMMIM]OAc and employed in the cyanosilylation of benzaldehyde 62 . Under relatively identical reaction conditions, cyanosilylation of benzaldehyde using [EMMIM]OAc as a catalyst gave 88% yield, which was comparable to the 94% yield afforded by 1a. As a consequence, we postulated that the in situ generated NHC may not play a significant role in the catalytic performance of 1a and a synergistic activation mode is probably the main reaction pathway (Fig. 1).

Conclusions
In conclusion, we have developed a highly efficient cyanosilylation reaction of carbonyl compounds using commercially and readily available [EMIM]OAc (1a) as an organocatalyst. In the presence of 0.0001-0.1 mol % of [EMIM]OAc, various aldehydes and ketones were converted to their corresponding products in excellent yields. The catalyst is truly active giving quite high TOF values from 10,843 h −1 to 10,602,410 h −1 , which is among the most efficient organocatalysts. Mechanistic investigations based on experimental results revealed that the reaction operates via a synergistic activation mode, namely, imidazolium cation interacts with carbonyl compounds by facilitating the attack of acetate anion activated TMSCN. From a practical point of view, this protocol offers a cost effective and facile way for the synthesis of cyanohydrins. Asymmetric cyanosilylation of carbonyl compounds using imidazolium-based chiral ILs is under investigation in our laboratory and will be reported in due course.

Methods
General procedure for cyanosilylation of carbonyl compounds (benzaldehyde as a typical example with TMSCN catalyzed by IL [EMIM]OAc (1a)). Caution. TMSCN must be used in a well-ventilated hood due to its high toxicity.
The reaction was carried out by placing freshly distilled TMSCN (1.2 mmol), 1a (0.005 mol %), and a teflon-coated magnetic stir bar into a Pyrex-glass screw cap vial. The solvent-free reaction was initiated by addition of freshly distilled benzaldehyde (1.0 mmol) and was stirred vigorously at room temperature. The reaction was monitored by TLC. After 5 minutes, the yield of benzaldehyde to its corresponding silylated cyanohydrin was determined by 1 H NMR as 94%. For all other carbonyl compounds the same procedure with the same amount of reagents were used, as described earlier in Tables 1-4. In case of aldehydes the yields were determined by 1 H NMR, whereas the yields of ketones were isolated by flash column chromatography on silica gel (eluent: n-hexane/ethyl acetate 40:1). All silylated cyanohydrin products of respective carbonyl compounds with TMSCN were confirmed by comparison of their 1 H NMR spectral data with those of authentic data 13 .