Figure 7: Schematic representation of the proposed models of chromatin organization within sperm nuclei. | Scientific Reports

Figure 7: Schematic representation of the proposed models of chromatin organization within sperm nuclei.

From: A new model of sperm nuclear architecture following assessment of the organization of centromeres and telomeres in three-dimensions

Figure 7

Panel a presents a schematic representation of the hairpin-loop model in which there is a linear array of chromocenters (red), with the chromosome p- and q-arms (light blue and dark blue, respectively) stretching out toward the telomeres (green) which are localized at the “extreme periphery” of the nucleus. In panel b we present a refined version of the model which depicts a more segmented organization, with telomeres and chromocenters being localized throughout the nucleus. Upon fertilization, chromatin localized at the apical most region and situated near the nuclear envelope will be the first regions of the genome to enter the oocyte and be remodeled.

Back to article page