Table 4 Trend associations across groups divided by frequency of hypoglycemia and changes in IMT.

From: Relationship between frequency of hypoglycemic episodes and changes in carotid atherosclerosis in insulin-treated patients with type 2 diabetes mellitus

Variable Regression coefficient (95% Confidence Interval) P value
Change in mean IMT-CCA
Model 1 0.047 (0.019–0.075) <0.001
Model 2 0.048 (0.021–0.075) <0.001
Model 3 0.043 (0.016–0.070) 0.002
Model 4 0.050 (0.012–0.088) 0.01
Model 5 0.054 (0.015–0.093) 0.007
Model 6 0.052 (0.013–0.092) 0.01
Model 7 0.047 (0.005–0.088) 0.027
Model 8 0.044 (0.014–0.074) 0.005
Change in right max IMT-CCA
Model 1 0.052 (−0.014–0.118) 0.12
Model 2 0.064 (0.001–0.128) 0.045
Model 3 0.058 (−0.005–0.122) 0.073
Model 4 0.046 (−0.046–0.138) 0.33
Model 5 0.049 (−0.046–0.143) 0.31
Model 6 0.049 (−0.046–0.143) 0.31
Model 7 0.054 (−0.045–0.153) 0.28
Model 8 0.069 (−0.002–0.139) 0.058
Change in left max IMT-CCA
Model 1 0.077 (0.019–0.134) 0.009
Model 2 0.078 (0.026–0.130) 0.004
Model 3 0.070 (0.018–0.123) 0.009
Model 4 0.089 (0.014–0.164) 0.02
Model 5 0.093 (0.016–0.169) 0.017
Model 6 0.088 (0.012–0.164) 0.024
Model 7 0.082 (0.002–0.161) 0.045
Model 8 0.069 (0.011–0.127) 0.021
  1. Model 1: Trend estimation for linear trends across quintiles is based on linear regression analysis for continuous variables unadjusted (Model 1), adjusted for model 1 plus baseline IMT (Model 2), model 2 plus age, gender, baseline IMT and the original treatment group (Model 3), model 2 plus body mass index and current smoking (Model 4), model 4 plus HbA1c, total cholesterol, high density lipoprotein-cholesterol, triglyceride and systolic blood pressure (Model 5), model 4 plus estimated glomerular filtration rate, use of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, use of statins and use of anti-platelets (Model 6), model 6 plus the use of sulfonylurea, the use of glinides and the use of α-glucosidase inhibitors (Model 7), model 7 plus C-peptide, high-sensitivity C-reactive protein and interleukin (Model 8). CCA, common carotid artery; IMT, intima-media thickness.