Figure 4 : Overexpression of miR-124 increases hepatic lipogenesis.

From: MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3

Figure 4

(A) The expression of miR-124 was determined in the liver of C57BL/6 mice infected with adenovirus (Ad-) containing GFP or miR-124 (n = 8–10). (B–D) Liver TG content (B) and weight (C) and serum TG levels (D) in mice infected with Ad-GFP Ad-miR-124 (n = 8–10). (E) Representative histology (H&E, left) or Oil Red O (right) staining showing TG accumulation in livers from mice injected with miR-124 versus GFP adenovirus. Original magnification, x200. (F) Relative expression of SREBP-1c and Fasn in two groups of mice. (G) Pearson R and P value for normalized SREBP-1c and Fasn mRNA levels versus miR-124 expression in livers of mice (n = 17). *P < 0.05, **P < 0.01, ***P < 0.001.